Perforin and resistance to SARS coronavirus 2

In this brief perspective, we outline the role of perforin in the host response to viral infections and draw parallels between morbidity and mortality patterns associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the functionality of perforin (Fig 1). We also reference known genetic disorders relating to perforin and their potential relevance. Finally, based on our hypothesis, suggestions are made regarding how the...