The Journal of Allergy and Clinical Immunology
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As the novel coronavirus SARS-CoV-2 caused COVID-19 cases in the United States the initial test was developed and performed at the Center for Disease Control (CDC). As the number of cases increased the demand for tests multiplied, leading the CDC to utilize the Emergency Utilization Authorization to allow clinical and commercial laboratories to develop tests to detect the presence of the virus. Many nucleic acid tests based on reverse transcriptase-polymerase chain reaction (RT-PCR) were develop...
BACKGROUND: COVID-19 can manifest as a viral induced hyperinflammation with multi-organ involvement. Such patients often experience rapid deterioration and need for mechanical ventilation. Currently, no prospectively validated biomarker of impending respiratory failure is available. OBJECTIVE: We aimed to identify and prospectively validate biomarkers that allow the identification of patients in need of impending mechanical ventilation. METHODS: Patients with COVID-19 hospitalized from February ...
#1Ashley Budu-Aggrey (UoB: University of Bristol)H-Index: 6
#2Sarah H. Watkins (UoB: University of Bristol)H-Index: 3
Last. Jonas B. Nielsen (UM: University of Michigan)H-Index: 31
view all 15 authors...
#1Benjamin Ungar (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 2
#2Ana B. Pavel (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 12
Last. Yeriel Estrada (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 26
view all 17 authors...
#1Ala Woo (UOU: University of Ulsan)
#2Seung Won Lee (Sejong University)H-Index: 3
Last. Dong Keon YonH-Index: 2
view all 6 authors...
Abstract Background Evidence regarding the risk of cancer development after asthma diagnosis is controversial and inconclusive. Objective To determine if asthma is associated with an increased risk for incident cancer. Methods Two independent, population-based, longitudinal cohorts were examined, and estimated hazard ratios were determined using Cox regression. One group consisted of an unmatched cohort of 475,197 participants and a propensity score-matched cohort of 75,307 participants from the...
#1Ulrike Förster-Ruhrmann (Humboldt University of Berlin)
#2Agnieszka J. Szczepek (Humboldt University of Berlin)H-Index: 18
Last. habil Heidi Olze (Humboldt University of Berlin)
view all 4 authors...
#1Hiroki Kimura (UA: University of Arizona)
#2Dave Francisco (UA: University of Arizona)H-Index: 6
Last. Monica Kraft (UA: University of Arizona)H-Index: 59
view all 8 authors...
Abstract Background SARS-CoV-2 has dramatically changed our world, country, communities and families. There is controversy regarding risk factors for severe COVID-19 disease. It has been suggested that asthma and allergy are not highly represented as co-morbid conditions associated with COVID-19. Objective To extend our work in interleukin (IL)-13 biology to determine if airway epithelial cell expression of two key mediators critical for SARS-CoV-2 infection, angiotensin-converting enzyme 2 (ACE...
#1Tim Delemarre (UGent: Ghent University)H-Index: 1
#2Gabriele Holtappels (UGent: Ghent University)H-Index: 32
Last. Elien Gevaert (UGent: Ghent University)H-Index: 10
view all 7 authors...
Abstract Background Chronic rhinosinusitis without nasal polyps (CRSsNP) is mainly considered a type 1 mediated disease. The role and clinical significance of type 2 immune responses in CRSsNP have not been addressed sufficiently; a recent cluster analysis for CRS described the existence of a subgroup of CRSsNP patients with a type 2 inflammation. Objective We aimed to characterize the underlying type 2 immune response and its clinical significance in CRSsNP patients. Methods 240 CRSsNP patients...
#1Louise Cunningham (St Thomas' Hospital)H-Index: 1
#2Peter Simmonds (University of Oxford)H-Index: 117
Last. John McFadden (St Thomas' Hospital)H-Index: 37
view all 5 authors...
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