The Journal of Allergy and Clinical Immunology
Papers 41506
1 page of 4,151 pages (41.5k results)
#1Lars-Olaf Cardell (KI: Karolinska Institutet)H-Index: 36
#2Pär Stjärne (KI: Karolinska Institutet)H-Index: 16
Last.Claus Bachert (KI: Karolinska Institutet)H-Index: 87
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Abstract Following the trend in asthma, endotypes for chronic rhinosinusitis with nasal polyps (CRSwNP) have been established, with Type 2 immune reactions representing 80-100% of nasal polyp cases in Europe and the US. Endotyping is without doubt useful to predict the natural course of disease, to determine pharmacotherapy and the extent of surgery, and lately also to select patients for Type 2 biologics. However, with the opening of this new era of treatment, also limitations of the current po...
#1Marcus Shaker (Dartmouth–Hitchcock Medical Center)H-Index: 9
#2Dana WallaceH-Index: 30
Last.David A. Khan (UTSW: University of Texas Southwestern Medical Center)H-Index: 40
view all 47 authors...
#1Xingnan Li (UA: University of Arizona)H-Index: 19
#2Annette T. Hastie (Wake Forest University)H-Index: 26
Last.Eugene R. Bleecker (UA: University of Arizona)H-Index: 94
view all 18 authors...
#1Trine Bertelsen (Aarhus University Hospital)H-Index: 6
#2Christine Ljungberg (Aarhus University Hospital)H-Index: 2
Last.Claus Johansen (Aarhus University Hospital)H-Index: 25
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Abstract Background IκBζ plays a key role in psoriasis by mediating IL-17A-driven effects, but the molecular mechanism by which IL-17A regulates IκBζ expression is not clarified. Objective To explore the molecular transformation in psoriatic patients during anti-IL-17A (secukinumab) treatment with focus on IκBζ. Methods The study was an open-label, one arm, single center secukinumab treatment study that included 14 patients with plaque psoriasis. Skin biopsies and blood samples were collected on...
#1M. Reiger (TUM: Technische Universität München)H-Index: 2
#2Claudia Traidl-Hoffmann (TUM: Technische Universität München)H-Index: 37
Last.Avidan U. Neumann (TUM: Technische Universität München)H-Index: 1
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#1Nirmala Gonsalves (NU: Northwestern University)H-Index: 25
#2Seema S. Aceves (UCSD: University of California, San Diego)H-Index: 33
Eosinophilic esophagitis (EoE) is an eosinophil-rich, TH2 antigen–mediated disease of increasing pediatric and adult worldwide prevalence. Diagnosis requires greater than or equal to 15 eosinophils per high-power field on light microscopy. Symptoms reflect esophageal dysfunction, and typical endoscopic features include linear furrows, white plaques, and concentric rings. Progressive disease leads to pathologic tissue remodeling, with ensuing esophageal rigidity and loss of luminal diameter cause...
#1Robert D. Pesek (Arkansas Children's Hospital)H-Index: 5
#2Marc E. Rothenberg (Cincinnati Children's Hospital Medical Center)H-Index: 100
#1Sandra Ammann (University of Freiburg)H-Index: 11
#2Sebastian Fuchs (University of Freiburg)H-Index: 13
Last.Stephan Ehl (University of Freiburg)H-Index: 47
view all 20 authors...
#1Alexander Vargas-Hernández (BCM: Baylor College of Medicine)H-Index: 4
#2Agnieszka Witalisz-Siepracka (University of Veterinary Medicine Vienna)H-Index: 4
Last.Lisa R. Forbes (BCM: Baylor College of Medicine)H-Index: 16
view all 11 authors...
Abstract Background Patients with STAT5b deficiency have autoimmunity, recurrent infections and combined immune deficiency, which affects T-cell homeostasis and leads to natural killer (NK) cell impairment. Objective In this study, we characterized the NK cell defect in STAT5b-deficient human NK cells as well as Stat5b-/- mice. Methods We used multiparametric flow cytometry, functional NK cells assays, microscopy as well as a Stat5b-/- mouse model to elucidate the effect impaired and/or absent S...
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