High–molecular weight hyaluronan attenuates tubulointerstitial scarring in kidney injury
Abstract
Renal fibrosis features exaggerated inflammation, extracellular matrix (ECM) deposition, and peritubular capillary loss. We previously showed that IL-10 stimulates high-molecular weight hyaluronan (HMW-HA) expression by fibroblasts, and we hypothesize that HMW-HA attenuates renal fibrosis by reducing inflammation and ECM remodeling. We studied the effects of IL-10 overexpression on HA production and scarring in mouse models of unilateral...
Paper Details
Title
High–molecular weight hyaluronan attenuates tubulointerstitial scarring in kidney injury
Published Date
Jun 18, 2020
Journal
Volume
5
Issue
12
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