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#2Lina JiangH-Index: 1
Last. Hongyang LiuH-Index: 1
view all 23 authors...
BACKGROUND: Severe acute respiratory coronavirus 2 (SARS-CoV-2) caused coronavirus disease 2019 (COVID-19) has become a pandemic. This study addressed the clinical and immunopathological characteristics of severe COVID-19. METHODS: Sixty-nine COVID-19 patients were classified into as severe and non-severe groups to analyze their clinical and laboratory characteristics. A panel of blood cytokines was quantified over time. Biopsy specimens from two deceased cases were obtained for immunopathologic...
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#1Li YangH-Index: 3
Last. Jorge A. BezerraH-Index: 27
view all 8 authors...
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#1Liang ChengH-Index: 11
#2Haisheng YuH-Index: 10
Last. Lishan SuH-Index: 36
view all 8 authors...
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#1Xinyi WangH-Index: 1
#2Swathi BalajiH-Index: 15
Last. Paul F. AustinH-Index: 23
view all 14 authors...
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#2Jill P. BuyonH-Index: 78
Last. Yuji ZhangH-Index: 1
view all 21 authors...
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#1Inah Hwang (Cornell University)H-Index: 3
#2Heng Pan (Cornell University)H-Index: 5
Last. Jihye Paik (Cornell University)H-Index: 45
view all 6 authors...
Capicua (CIC), a member of the high mobility group (HMG)-box superfamily of transcriptional repressors, is frequently mutated in human oligodendrogliomas. But its function in brain development and tumorigenesis remains poorly understood. Here, we report that brain-specific deletion of Cic compromises developmental transition of neuroblast to immature neurons in mouse hippocampus and compromises normal neuronal differentiation. Combined gene expression and ChIP-seq analyses identified VGF as an i...
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#2Yifan SunH-Index: 1
Last. Yujing LiH-Index: 11
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Immune checkpoint blockade immunotherapy delivers promising clinical results in colorectal cancer (CRC). However, only a fraction of cancer patients develop durable responses. The tumor microenvironment (TME) negatively impacts tumor immunity and subsequently clinical outcomes. Therefore, there is a need to identify other checkpoint targets associated with the TME. Early-onset factors secreted by stromal cells as well as tumor cells often help recruit immune cells to the TME, among which are ala...
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#1Camilla Schinner (University of Basel)H-Index: 3
#2Bernd M. Erber (LMU: Ludwig Maximilian University of Munich)
Last. Jens Waschke (LMU: Ludwig Maximilian University of Munich)H-Index: 28
view all 10 authors...
Arrhythmogenic cardiomyopathy (AC) is a genetic disease causing arrhythmia and sudden cardiac death with only symptomatic therapy available at present. Mutations of desmosomal proteins, including desmoglein-2 (Dsg2) and plakoglobin (Pg), are the major cause of AC and have been shown to lead to impaired gap junction function. Recent data indicated the involvement of anti-Dsg2 autoantibodies in AC pathogenesis. We applied a peptide to stabilize Dsg2 binding similar to a translational approach to p...
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#2Shyh-Ing JangH-Index: 4
Last. Ilias AlevizosH-Index: 19
view all 9 authors...
Sjogren's syndrome (SS) is a systemic autoimmune disease that mainly affects exocrine salivary and lacrimal glands. Local inflammation in the glands is thought to trigger glandular dysfunction and symptoms of dryness. However, the mechanisms underlying these processes are incompletely understood. Our work suggests T cell exosome-derived miR-142-3p as a pathogenic driver of immunopathology in SS. We first document miR-142-3p expression in the salivary glands of patients with SS, both in epithelia...
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#1Melinda A. Biernacki (Fred Hutchinson Cancer Research Center)H-Index: 1
#2Vipul S. Sheth (Fred Hutchinson Cancer Research Center)
Last. Marie Bleakley (UW: University of Washington)H-Index: 16
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Protection from relapse after allogeneic hematopoietic cell transplantation (HCT) is partly due to donor T cell-mediated graft-versus-leukemia (GVL) immune responses. Relapse remains common in HCT recipients, but strategies to augment GVL could significantly improve outcomes after HCT. Donor T cells with alphabeta T cell receptors (TCRs) mediate GVL through recognition of minor histocompatibility antigens and alloantigens in HLA-matched and -mismatched HCT, respectively. alphabeta T cells specif...
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