Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19

BackgroundCoronavirus disease 2019 (COVID-19) can manifest as a viral-induced hyperinflammation with multiorgan involvement. Such patients often experience rapid deterioration and need for mechanical ventilation. Currently, no prospectively validated biomarker of impending respiratory failure is available.ObjectiveWe aimed to identify and prospectively validate biomarkers that allow the identification of patients in need of impending mechanical...