12 Therapeutic Drug Monitoring in the relapse prevention treatment of alcohol dependence

Introduction Therapeutic drug monitoring has not been used to optimize and individualize drug effects in anti-craving treatment in alcohol use disorders (AUD) up to now. One compound of common use, naltrexone, shows high inter-individual variability in both plasma availability and treatment outcome. We present data aiming at the definition of a therapeutic plasma concentrations of naltrexone and its active metabolite 6β-naltrexol that are...