Major Dysregulated Gene Sets and Increased RNA Editing in PolyI:C Treated Mice May Contribute to the Emergence of Major Neurodevelopmental Disorders

The etiology of major neurodevelopmental disorders (NMD) such as Schizophrenia and Autism is unclear with evidence supporting a combination of polygenic susceptibility and exposure to environmental risk which can impair neurodevelopment. Maternal immune activation (MIA) models in rodents are based on observations that viral infection during pregnancy causes an immune activation which puts the offspring at higher risk for developing SCZ. Here we...