Erez Y. Levanon
Bar-Ilan University
GeneRNA editingGeneticsRNABiology
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Publications 103
#1Amos A. Schaffer (BIU: Bar-Ilan University)H-Index: 1
#2Eli Kopel (BIU: Bar-Ilan University)H-Index: 2
Last. Eli Eisenberg (TAU: Tel Aviv University)H-Index: 32
view all 6 authors...
Adenosine-to-inosine (A-to-I) RNA editing is a common post transcriptional modification. It has a critical role in protecting against false activation of innate immunity by endogenous double stranded RNAs and has been associated with various regulatory processes and diseases such as autoimmune and cardiovascular diseases as well as cancer. In addition, the endogenous A-to-I editing machinery has been recently harnessed for RNA engineering. The study of RNA editing in humans relies heavily on the...
1 CitationsSource
#1Michal Barak (BIU: Bar-Ilan University)H-Index: 13
#2Hagit T. Porath (BIU: Bar-Ilan University)H-Index: 10
Last. Eli Eisenberg (TAU: Tel Aviv University)H-Index: 32
view all 8 authors...
BACKGROUND: Mobile elements comprise a large fraction of metazoan genomes. Accumulation of mobile elements is bound to produce multiple putative double-stranded RNA (dsRNA) structures within the transcriptome. These endogenous dsRNA structures resemble viral RNA and may trigger false activation of the innate immune response, leading to severe damage to the host cell. Adenosine to inosine (A-to-I) RNA editing is a common post-transcriptional modification, abundant within repetitive elements of al...
#1Alessandro Esposito (IIT: Istituto Italiano di Tecnologia)H-Index: 24
#2Antonio Falace (UniFI: University of Florence)H-Index: 12
Last. Renzo Guerrini (UniFI: University of Florence)H-Index: 82
view all 28 authors...
Ohtahara syndrome, early infantile epileptic encephalopathy with a suppression burst EEG pattern, is an aetiologically heterogeneous condition starting in the first weeks or months of life with intractable seizures and profound developmental disability. Using whole exome sequencing, we identified biallelic DMXL2 mutations in three sibling pairs with Ohtahara syndrome, belonging to three unrelated families. Siblings in Family 1 were compound heterozygous for the c.5135C>T (p.Ala1712Val) missense ...
2 CitationsSource
#1Shalom Hillel Roth (BIU: Bar-Ilan University)H-Index: 2
#2Erez Y. Levanon (BIU: Bar-Ilan University)H-Index: 34
Last. Eli Eisenberg (TAU: Tel Aviv University)H-Index: 32
view all 3 authors...
Adenosine-to-inosine (A-to-I) RNA editing by the adenosine deaminase that acts on RNA (ADAR) enzymes is a common RNA modification, preventing false activation of the innate immune system by endogenous double-stranded RNAs. Methods for quantification of ADAR activity are sought after, due to an increasing interest in the role of ADARs in cancer and autoimmune disorders, as well as attempts to harness the ADAR enzymes for RNA engineering. Here, we present the Alu editing index (AEI), a robust and ...
9 CitationsSource
#1Alec L.W. Dick (MPG: Max Planck Society)H-Index: 6
#2Khen KhermeshH-Index: 3
Last. Alon Chen (Weizmann Institute of Science)H-Index: 42
view all 6 authors...
Adenosine to inosine (A-to-I) RNA editing is a co/post-transcriptional modification of double stranded RNA, catalysed by the adenosine deaminase acting on RNA (ADAR) family of enzymes, which results in recognition of inosine as guanosine by translational and splicing machinery causing potential recoding events in amino acid sequences. A-to-I editing is prominent within brain-specific transcripts and dysregulation of editing at several well-studied loci (e.g., Gria2, Htr2c) has been implicated in...
#1Polina Denichenko (HUJI: Hebrew University of Jerusalem)H-Index: 4
#2Maxim Mogilevsky (HUJI: Hebrew University of Jerusalem)H-Index: 5
Last. Rotem Karni (HUJI: Hebrew University of Jerusalem)H-Index: 24
view all 15 authors...
Alternative splicing, a fundamental step in gene expression, is deregulated in many diseases. Splicing factors (SFs), which regulate this process, are up- or down regulated or mutated in several diseases including cancer. To date, there are no inhibitors that directly inhibit the activity of SFs. We designed decoy oligonucleotides, composed of several repeats of a RNA motif, which is recognized by a single SF. Here we show that decoy oligonucleotides targeting splicing factors RBFOX1/2, SRSF1 an...
1 CitationsSource
#1Hagit T. Porath (BIU: Bar-Ilan University)H-Index: 10
#2Esther Hazan (HUJI: Hebrew University of Jerusalem)H-Index: 2
Last. Guy Bloch (HUJI: Hebrew University of Jerusalem)H-Index: 34
view all 9 authors...
Colonies of the bumblebee Bombus terrestris are characterized by wide phenotypic variability among genetically similar full-sister workers, suggesting a major role for epigenetic processes. Here, we report a high level of ADAR-mediated RNA editing in the bumblebee, despite the lack of an ADAR1-homolog. We identify 1.15 million unique genomic sites, and 164 recoding sites residing in 100 protein coding genes, including ion channels, transporters, and receptors predicted to affect brain function a...
2 CitationsSource
#1Yishay Pinto (BIU: Bar-Ilan University)H-Index: 7
#2Erez Y. Levanon (BIU: Bar-Ilan University)H-Index: 34
Abstract Adenosine deaminases that act on RNA (ADARs) catalyze adenosine-to-inosine (A-to-I) RNA editing in double-stranded RNA. Such editing is important for protection against false activation of the immune system, but also confers plasticity on the transcriptome by generating several versions of a transcript from a single genomic locus. Recently, great efforts were made in developing computational methods for detecting editing events directly from RNA-sequencing (RNA-seq) data. These efforts ...
#1Jeffrey J. Ishizuka (MIT: Massachusetts Institute of Technology)H-Index: 3
#2Robert T. Manguso (MIT: Massachusetts Institute of Technology)H-Index: 5
Last. W. Nicholas Haining (MIT: Massachusetts Institute of Technology)H-Index: 36
view all 27 authors...
Most patients with cancer either do not respond to immune checkpoint blockade or develop resistance to it, often because of acquired mutations that impair antigen presentation. Here we show that loss of function of the RNA-editing enzyme ADAR1 in tumour cells profoundly sensitizes tumours to immunotherapy and overcomes resistance to checkpoint blockade. In the absence of ADAR1, A-to-I editing of interferon-inducible RNA species is reduced, leading to double-stranded RNA ligand sensing by PKR and...
33 CitationsSource