Match!
Erez Y. Levanon
Bar-Ilan University
108Publications
33H-index
7,015Citations
Publications 108
Newest
#1Hagit T. Porath (BIU: Bar-Ilan University)H-Index: 10
#2Esther Hazan (HUJI: Hebrew University of Jerusalem)H-Index: 2
Last.Guy Bloch (HUJI: Hebrew University of Jerusalem)H-Index: 33
view all 9 authors...
Colonies of the bumblebee Bombus terrestris are characterized by wide phenotypic variability among genetically similar full-sister workers, suggesting a major role for epigenetic processes. Here, we report a high level of ADAR-mediated RNA editing in the bumblebee, despite the lack of an ADAR1-homolog. We identify 1.15 million unique genomic sites, and 164 recoding sites residing in 100 protein coding genes, including ion channels, transporters, and receptors predicted to affect brain function a...
#1Polina Denichenko (HUJI: Hebrew University of Jerusalem)H-Index: 3
#2Maxim Mogilevsky (HUJI: Hebrew University of Jerusalem)H-Index: 3
Last.Rotem Karni (HUJI: Hebrew University of Jerusalem)H-Index: 21
view all 15 authors...
Alternative splicing, a fundamental step in gene expression, is deregulated in many diseases. Splicing factors (SFs), which regulate this process, are up- or down regulated or mutated in several diseases including cancer. To date, there are no inhibitors that directly inhibit the activity of SFs. We designed decoy oligonucleotides, composed of several repeats of a RNA motif, which is recognized by a single SF. Here we show that decoy oligonucleotides targeting splicing factors RBFOX1/2, SRSF1 an...
#1Shalom Hillel Roth (BIU: Bar-Ilan University)H-Index: 1
#2Erez Y. Levanon (BIU: Bar-Ilan University)H-Index: 33
Last.Eli Eisenberg (TAU: Tel Aviv University)H-Index: 31
view all 3 authors...
Adenosine-to-inosine (A-to-I) RNA editing by the adenosine deaminase that acts on RNA (ADAR) enzymes is a common RNA modification, preventing false activation of the innate immune system by endogenous double-stranded RNAs. Methods for quantification of ADAR activity are sought after, due to an increasing interest in the role of ADARs in cancer and autoimmune disorders, as well as attempts to harness the ADAR enzymes for RNA engineering. Here, we present the Alu editing index (AEI), a robust and ...
#1Alec L.W. Dick (MPG: Max Planck Society)H-Index: 6
#2Khen KhermeshH-Index: 3
Last.Alon Chen (Weizmann Institute of Science)H-Index: 36
view all 6 authors...
Adenosine to inosine (A-to-I) RNA editing is a co/post-transcriptional modification of double stranded RNA, catalysed by the adenosine deaminase acting on RNA (ADAR) family of enzymes, which results in recognition of inosine as guanosine by translational and splicing machinery causing potential recoding events in amino acid sequences. A-to-I editing is prominent within brain-specific transcripts and dysregulation of editing at several well-studied loci (e.g., Gria2, Htr2c) has been implicated in...
#1Yishay Pinto (BIU: Bar-Ilan University)H-Index: 6
#2Erez Y. Levanon (BIU: Bar-Ilan University)H-Index: 33
Abstract Adenosine deaminases that act on RNA (ADARs) catalyze adenosine-to-inosine (A-to-I) RNA editing in double-stranded RNA. Such editing is important for protection against false activation of the immune system, but also confers plasticity on the transcriptome by generating several versions of a transcript from a single genomic locus. Recently, great efforts were made in developing computational methods for detecting editing events directly from RNA-sequencing (RNA-seq) data. These efforts ...
#1Jeffrey J. Ishizuka (MIT: Massachusetts Institute of Technology)H-Index: 2
#2Robert T. Manguso (MIT: Massachusetts Institute of Technology)H-Index: 5
Last.W. Nicholas Haining (MIT: Massachusetts Institute of Technology)H-Index: 34
view all 27 authors...
Most patients with cancer either do not respond to immune checkpoint blockade or develop resistance to it, often because of acquired mutations that impair antigen presentation. Here we show that loss of function of the RNA-editing enzyme ADAR1 in tumour cells profoundly sensitizes tumours to immunotherapy and overcomes resistance to checkpoint blockade. In the absence of ADAR1, A-to-I editing of interferon-inducible RNA species is reduced, leading to double-stranded RNA ligand sensing by PKR and...
#1Serghei Mangul (UCLA: University of California, Los Angeles)H-Index: 12
#2Harry Taegyun Yang (UCLA: University of California, Los Angeles)H-Index: 5
Last.Noah Zaitlen (UCSF: University of California, San Francisco)H-Index: 32
view all 24 authors...
High-throughput RNA-sequencing (RNA-seq) technologies provide an unprecedented opportunity to explore the individual transcriptome. Unmapped reads are a large and often overlooked output of standard RNA-seq analyses. Here, we present Read Origin Protocol (ROP), a tool for discovering the source of all reads originating from complex RNA molecules. We apply ROP to samples across 2630 individuals from 54 diverse human tissues. Our approach can account for 99.9% of 1 trillion reads of various read l...
#1Hugh S. Gannon (Broad Institute)H-Index: 3
#2Tao Zou (Broad Institute)H-Index: 1
Last.Matthew MeyersonH-Index: 160
view all 16 authors...
Systematic exploration of cancer cell vulnerabilities can inform the development of novel cancer therapeutics. Here, through analysis of genome-scale loss-of-function datasets, we identify adenosine deaminase acting on RNA (ADAR or ADAR1) as an essential gene for the survival of a subset of cancer cell lines. ADAR1-dependent cell lines display increased expression of interferon-stimulated genes. Activation of type I interferon signaling in the context of ADAR1 deficiency can induce cell lethalit...
#1Mamta Jain (Medical University of Vienna)H-Index: 1
#2Tomer D Mann (BIU: Bar-Ilan University)H-Index: 1
Last.Michael F. Jantsch (Medical University of Vienna)H-Index: 31
view all 24 authors...
Abstract Epitranscriptomic events such as adenosine‐to‐inosine (A‐to‐I) RNA editing by ADAR can recode mRNAs to translate novel proteins. Editing of the mRNA that encodes actin crosslinking protein Filamin A (FLNA) mediates a Q‐to‐R transition in the interactive C‐terminal region. While FLNA editing is conserved among vertebrates, its physiological function remains unclear. Here, we show that cardiovascular tissues in humans and mice show massive editing and that FLNA RNA is the most prominent s...
#1Eli Eisenberg (TAU: Tel Aviv University)H-Index: 31
#2Erez Y. Levanon (BIU: Bar-Ilan University)H-Index: 33
Modifications of RNA affect its function and stability. RNA editing is unique among these modifications because it not only alters the cellular fate of RNA molecules but also alters their sequence relative to the genome. The most common type of RNA editing is A-to-I editing by double-stranded RNA-specific adenosine deaminase (ADAR) enzymes. Recent transcriptomic studies have identified a number of ‘recoding’ sites at which A-to-I editing results in non-synonymous substitutions in protein-coding ...
12345678910