Original paper

BRCA1 Mutational Complementation Induces Synthetic Viability

Volume: 78, Issue: 5, Pages: 951 - 959.e6
Published: Jun 1, 2020
Abstract
BRCA1 promotes the DNA end resection and RAD51 loading steps of homologous recombination (HR). Whether these functions can be uncoupled, and whether mutant proteins retaining partial activity can complement one another, is unclear and could affect the severity of BRCA1-associated Fanconi anemia (FA). Here we generated a Brca1CC mouse with a coiled-coil (CC) domain deletion. Brca1CC/CC mice are born at low frequencies, and post-natal mice have...
Paper Details
Title
BRCA1 Mutational Complementation Induces Synthetic Viability
Published Date
Jun 1, 2020
Volume
78
Issue
5
Pages
951 - 959.e6
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