Molecular Cell
Papers 7800
1 page of 780 pages (7,800 results)
#1Xijuan Liu (UNC: University of North Carolina at Chapel Hill)H-Index: 1
#2Jeremy M. Simon (UNC: University of North Carolina at Chapel Hill)H-Index: 17
Last.Xianming Tan (UNC: University of North Carolina at Chapel Hill)H-Index: 16
view all 17 authors...
Summary von Hippel-Lindau (VHL) is a critical tumor suppressor in clear cell renal cell carcinomas (ccRCCs). It is important to identify additional therapeutic targets in ccRCC downstream of VHL loss besides hypoxia-inducible factor 2α (HIF2α). By performing a genome-wide screen, we identified Scm-like with four malignant brain tumor domains 1 (SFMBT1) as a candidate pVHL target. SFMBT1 was considered to be a transcriptional repressor but its role in cancer remains unclear. ccRCC patients with V...
#1Niklas Mejhert (Harvard University)H-Index: 3
#2Leena Kuruvilla (Yale University)H-Index: 7
Last.Nika N. Danial (Harvard University)H-Index: 32
view all 12 authors...
Summary Lipid droplets (LDs) store lipids for energy and are central to cellular lipid homeostasis. The mechanisms coordinating lipid storage in LDs with cellular metabolism are unclear but relevant to obesity-related diseases. Here we utilized genome-wide screening to identify genes that modulate lipid storage in macrophages, a cell type involved in metabolic diseases. Among ∼550 identified screen hits is MLX, a basic helix-loop-helix leucine-zipper transcription factor that regulates metabolic...
#1Shan-Ho Chou (NCHU: National Chung Hsing University)H-Index: 21
#2Michael Y. Galperin (NIH: National Institutes of Health)H-Index: 75
A recent paper by Gallagher et al. (2020) demonstrates that c-di-GMP controls spore formation in Streptomyces venezuelae through sequestering the sporulation sigma factor σWhiG and presents the crystal structure of a ternary complex between c-di-GMP, σWhiG, and its anti-sigma factor, RsiG.
#1Hannah R. Kempton (Stanford University)
#2Laine E. Goudy (Stanford University)
Last.Lei S. Qi (Stanford University)H-Index: 30
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Summary The ability to integrate biological signals and execute a functional response when appropriate is critical for sophisticated cell engineering using synthetic biology. Although the CRISPR-Cas system has been harnessed for synthetic manipulation of the genome, it has not been fully utilized for complex environmental signal sensing, integration, and actuation. Here, we develop a split dCas12a platform and show that it allows for the construction of multi-input, multi-output logic circuits i...
#1Rati Verma (Amgen)
#2Dane Mohl (Amgen)
Last.Raymond J. Deshaies (Amgen)
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Two decades into the twenty-first century, a confluence of breakthrough technologies wielded at the molecular level is presenting biologists with unique opportunities to unravel the complexities of the cellular world. CRISPR/Cas9 allows gene knock-outs, knock-ins, and single-base editing at chromosomal loci. RNA-based tools such as siRNA, antisense oligos, and morpholinos can be used to silence expression of specific genes. Meanwhile, protein knockdown tools that draw inspiration from natural re...
#1Annabel Quinet (WashU: Washington University in St. Louis)
#2Annabel Quinet (WashU: Washington University in St. Louis)H-Index: 11
Last.Alessandro Vindigni (SLU: Saint Louis University)H-Index: 9
view all 15 authors...
Summary Acute treatment with replication-stalling chemotherapeutics causes reversal of replication forks. BRCA proteins protect reversed forks from nucleolytic degradation, and their loss leads to chemosensitivity. Here, we show that fork degradation is no longer detectable in BRCA1-deficient cancer cells exposed to multiple cisplatin doses, mimicking a clinical treatment regimen. This effect depends on increased expression and chromatin loading of PRIMPOL and is regulated by ATR activity. Elect...
1 CitationsSource
#1Xin Wang (CAS: Chinese Academy of Sciences)H-Index: 1
#2Zhi-Tong Li (CAS: Chinese Academy of Sciences)H-Index: 1
Last.Hui-Tao Qi (CAS: Chinese Academy of Sciences)H-Index: 1
view all 20 authors...
Summary U6 snRNA, as an essential component of the catalytic core of the pre-mRNA processing spliceosome, is heavily modified post-transcriptionally, with 2′-O-methylation being most common. The role of these modifications in pre-mRNA splicing as well as their physiological function in mammals have remained largely unclear. Here we report that the La-related protein LARP7 functions as a critical cofactor for 2′-O-methylation of U6 in mouse male germ cells. Mechanistically, LARP7 promotes U6 load...
1 CitationsSource
#1Kelley A. Gallagher (Norwich Research Park)H-Index: 1
#2Maria A. Schumacher (Duke University)H-Index: 42
Last.Mark J. Buttner (Norwich Research Park)H-Index: 55
view all 12 authors...
Summary Streptomyces are our primary source of antibiotics, produced concomitantly with the transition from vegetative growth to sporulation in a complex developmental life cycle. We previously showed that the signaling molecule c-di-GMP binds BldD, a master repressor, to control initiation of development. Here we demonstrate that c-di-GMP also intervenes later in development to control differentiation of the reproductive hyphae into spores by arming a novel anti-σ (RsiG) to bind and sequester a...
1 CitationsSource
#1Maria Ninova (California Institute of Technology)H-Index: 12
#2Yung-Chia Ariel Chen (California Institute of Technology)H-Index: 3
Last.Alexei A. Aravin (California Institute of Technology)H-Index: 37
view all 7 authors...
Summary Regulation of transcription is the main mechanism responsible for precise control of gene expression. Whereas the majority of transcriptional regulation is mediated by DNA-binding transcription factors that bind to regulatory gene regions, an elegant alternative strategy employs small RNA guides, Piwi-interacting RNAs (piRNAs) to identify targets of transcriptional repression. Here, we show that in Drosophila the small ubiquitin-like protein SUMO and the SUMO E3 ligase Su(var)2-10 are re...
1 CitationsSource
#1Yuqing Wu (Nanjing Medical University)H-Index: 1
#2Yingchao Hu (Nanjing Medical University)H-Index: 1
Last.Shuo Yang (Nanjing Medical University)H-Index: 1
view all 9 authors...
Summary The functional relevance and mechanistic basis of the effects of the neurotransmitter dopamine (DA) on inflammation remain unclear. Here we reveal that DA inhibited TLR2-induced NF-κB activation and inflammation via the DRD5 receptor in macrophages. We found that the DRD5 receptor, via the EFD and IYX(X)I/L motifs in its CT and IC3 loop, respectively, can directly recruit TRAF6 and its negative regulator ARRB2 to form a multi-protein complex also containing downstream signaling proteins,...
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Molecular biology
Cell biology