Molecular Cell
Papers 7824
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#1Sang-Ah Kim (PSU: Pennsylvania State University)
#2Jiang Zhu (PSU: Pennsylvania State University)
Last. Song Tan (PSU: Pennsylvania State University)H-Index: 33
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Summary LSD1 (lysine specific demethylase; also known as KDM1A), the first histone demethylase discovered, regulates cell-fate determination and is overexpressed in multiple cancers. LSD1 demethylates histone H3 Lys4, an epigenetic mark for active genes, but requires the CoREST repressor to act on nucleosome substrates. To understand how an accessory subunit (CoREST) enables a chromatin enzyme (LSD1) to function on a nucleosome and not just histones, we have determined the crystal structure of t...
#1Xudong Zhang (UCR: University of California, Riverside)
#2Qi Chen (UCR: University of California, Riverside)
Yoshida et al. (2020) report in this issue of Molecular Cell that a paternal low-protein diet elevates ROS in the testicular germ cells, altering ATF7 activity and H3K9me2 abundance on target genes, including tRNA loci. These changes are maintained in spermatozoa, regulating tsRNA biogenesis, and together transmit intergenerational effects.
#1Jonne A. Raaijmakers (NKI-AVL: Netherlands Cancer Institute)H-Index: 11
#2René H. Medema (NKI-AVL: Netherlands Cancer Institute)H-Index: 65
Michowski and colleagues (2020) engineered analog-sensitive Cdk1 knockin mice to identify Cdk1 targets in embryonic stem cells, which led them to discover a novel function for Cdk1 in shaping the epigenetic landscape by direct regulation of epigenetic modulators.
#1Li-Hsin Chang (Université Paris-Saclay)
#2Daan Noordermeer (Université Paris-Saclay)H-Index: 1
Using Micro-C, Hsieh et al. (2020) and Krietenstein et al. (2020) investigated 3D chromatin folding in human and mouse cells at unprecedented resolution to uncover ultra-fine-scale chromatin structures that provide direct links between genome architecture, gene expression, and gene regulation.
#1Xiaotian Zhang (BCM: Baylor College of Medicine)H-Index: 11
#2Mira Jeong (BCM: Baylor College of Medicine)H-Index: 26
Last. Yushuai Liu (Van Andel Institute)
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Summary Higher-order chromatin structure and DNA methylation are implicated in multiple developmental processes, but their relationship to cell state is unknown. Here, we find that large (>7.3 kb) DNA methylation nadirs (termed “grand canyons”) can form long loops connecting anchor loci that may be dozens of megabases (Mb) apart, as well as inter-chromosomal links. The interacting loci cover a total of ∼3.5 Mb of the human genome. The strongest interactions are associated with repressive marks m...
#1Debjani Bhattacharya (LMU: Ludwig Maximilian University of Munich)
#2Christian Behrends (LMU: Ludwig Maximilian University of Munich)H-Index: 22
Fujioka et al. (2020) uncovered liquid-liquid phase separation of the PAS, a key driver of autophagosome formation in yeast. Moreover, the authors demonstrated that liquid-like PAS controls autophagic kinase activation and is itself regulated by the phosphorylation status of its constituents.
#1Bethan Psaila (NIH: National Institutes of Health)
#2Guanlin WangH-Index: 1
Last. J O'Sullivan (University of Oxford)H-Index: 1
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Summary Myelofibrosis is a severe myeloproliferative neoplasm characterized by increased numbers of abnormal bone marrow megakaryocytes that induce fibrosis, destroying the hematopoietic microenvironment. To determine the cellular and molecular basis for aberrant megakaryopoiesis in myelofibrosis, we performed single-cell transcriptome profiling of 135,929 CD34+ lineage− hematopoietic stem and progenitor cells (HSPCs), single-cell proteomics, genomics, and functional assays. We identified a bias...
#1Byungil Kim (Vandy: Vanderbilt University)H-Index: 1
#2Sarah E Arcos (Vandy: Vanderbilt University)
Last. Shelton S. Bradrick (UTMB: University of Texas Medical Branch)H-Index: 22
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Summary The primary interactions between incoming viral RNA genomes and host proteins are crucial to infection and immunity. Until now, the ability to study these events was lacking. We developed viral cross-linking and solid-phase purification (VIR-CLASP) to characterize the earliest interactions between viral RNA and cellular proteins. We investigated the infection of human cells using Chikungunya virus (CHIKV) and influenza A virus and identified hundreds of direct RNA-protein interactions. H...
#1Poonam BhedaH-Index: 5
#2Diana Aguilar‐Gómez (UNAM: National Autonomous University of Mexico)H-Index: 1
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Summary Transcriptional memory of gene expression enables adaptation to repeated stimuli across many organisms. However, the regulation and heritability of transcriptional memory in single cells and through divisions remains poorly understood. Here, we combined microfluidics with single-cell live imaging to monitor Saccharomyces cerevisiae galactokinase 1 (GAL1) expression over multiple generations. By applying pedigree analysis, we dissected and quantified the maintenance and inheritance of tra...
#1Joseph Nacson (TU: Temple University)H-Index: 1
#2Daniela Di Marcantonio (Fox Chase Cancer Center)H-Index: 4
Last. Elsa CallénH-Index: 10
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Summary BRCA1 promotes the DNA end resection and RAD51 loading steps of homologous recombination (HR). Whether these functions can be uncoupled, and whether mutant proteins retaining partial activity can complement one another, is unclear and could affect the severity of BRCA1-associated Fanconi anemia (FA). Here we generated a Brca1CC mouse with a coiled-coil (CC) domain deletion. Brca1CC/CC mice are born at low frequencies, and post-natal mice have FA-like abnormalities, including bone marrow ...
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