Computationally designed synthetic peptides for transporter proteins imparts allostericity in Miltefosine resistant L. major
Abstract
The emergence of drug resistance is a major concern for combating against Cutaneous Leishmaniasis, a neglected tropical disease affecting 98 countries including India. Miltefosine is the only oral drug available for the disease and Miltefosine transporter proteins play a pivotal role in the emergence of drug-resistant Leishmania major. The cause of resistance is less accumulation of drug inside the parasite either by less uptake of the drug due...
Paper Details
Title
Computationally designed synthetic peptides for transporter proteins imparts allostericity in Miltefosine resistant L. major
Published Date
May 29, 2020
Journal
Volume
477
Issue
10
Pages
2007 - 2026
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