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Biochemical Journal
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#1Priyanka Kumari (JU: Jiwaji University)
#1Priyanka Kumari (AIIMS: All India Institute of Medical Sciences)H-Index: 3
Last. Jaya Sivaswami Tyagi (AIIMS: All India Institute of Medical Sciences)H-Index: 30
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The DevR-DevS/DosR-DosS two-component system of Mycobacterium tuberculosis, that comprises of DevS sensor kinase and DevR response regulator, is essential for bacterial adaptation to hypoxia by inducing dormancy regulon expression. The dominant phosphatase activity of DevS under aerobic conditions enables tight negative control, whereas its kinase function activates DevR under hypoxia to induce the dormancy regulon. A net balance in these opposing kinase and phosphatase activities of DevS calibr...
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#1Y. T. HuH-Index: 4
#2Xuemei Bai (HUST: Huazhong University of Science and Technology)
Last. Qiuyun Chen (Cleveland Clinic Lerner College of Medicine)H-Index: 17
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Cardiac sodium channel Nav1.5 is associated with cardiac arrhythmias and heart failure. Protein ubiquitination is catalyzed by an E1-E2-E3 cascade of enzymes. However, the E1 enzyme catalyzing Nav1.5 ubiquitination is unknown. Here, we show that UBE1 and UBA6 are two E1 enzymes regulating Nav1.5 ubiquitination and expression. Western blot analysis and patch-clamping recordings showed that overexpression of UBE1 or UBA6 increased ubiquitination of Nav1.5 and significantly reduced Nav1.5 expressio...
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#1Hala Ouzon-Shubeita (University of Texas at Austin)H-Index: 3
#2Hunmin Jung (University of Texas at Austin)
Last. Seongmin Lee (University of Texas at Austin)H-Index: 16
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Thymine:guanine base pairs are major promutagenic mismatches occurring in DNA metabolism. If left unrepaired, these mispairs can cause C to T transition mutations. In humans, T:G mismatches are repaired in part by mismatch-specific DNA glycosylases such as methyl-CpG-binding domain 4 (hMBD4) and thymine DNA glycosylase. Unlike lesion-specific DNA glycosylases, T:G-mismatch-specific DNA glycosylases specifically recognize both bases of the mismatch and remove the thymine but only from mispairs wi...
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#1Felix Buchert (WWU: University of Münster)
#2Laura Mosebach (WWU: University of Münster)H-Index: 1
Last. Michael Hippler (WWU: University of Münster)H-Index: 42
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Proton Gradient Regulation 5 (PGR5) is involved in the control of photosynthetic electron transfer, but its mechanistic role is not yet clear. Several models have been proposed to explain phenotypes such as a diminished steady state proton motive force (pmf) and increased photodamage of photosystem I (PSI). Playing a regulatory role in cyclic electron flow (CEF) around PSI, PGR5 contributes indirectly to PSI protection by enhancing photosynthetic control, which is a pH-dependent downregulation o...
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#1Cunjia Qiu (ND: University of Notre Dame)H-Index: 3
#2Yue Yuan (ND: University of Notre Dame)H-Index: 2
Last. Francis J. Castellino (ND: University of Notre Dame)H-Index: 58
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Plasminogen-binding group A streptococcal M-protein (PAM) is a signature surface virulence factor of specific strains of Group A Streptococcuspyogenes (GAS) and is an important tight binding protein for human plasminogen (hPg). After activation of PAM-bound hPg to the protease, plasmin (hPm), GAS cells develop invasive surfaces that are critical for their pathogenicity. PAMs are helical dimers in solution, which are sensitive to temperature changes over a physiological temperature range. We prev...
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#1Ravi Jain (Shiv Nadar University)
#2Sakshi Gupta (JNU: Jawaharlal Nehru University)H-Index: 1
Last. Shailja Singh (JNU: Jawaharlal Nehru University)H-Index: 26
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#1Chenyi Tang (CSU: Central South University)
#2Wei Chen (UAB: University of Alabama at Birmingham)H-Index: 20
Last. Yi-Ping Li (UAB: University of Alabama at Birmingham)H-Index: 31
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One of the fundamental questions in bone biology is where osteoblasts originate and how osteoblast differentiation is regulated. The mechanism underlying which factors regulate chondrocyte to osteoblast lineage commitment remains unknown. Our data showed that Runt-related transcription factor 1 (Runx1) is expressed at different stages of both chondrocyte and osteoblast differentiation. Runx1 chondrocyte-specific knockout (Runx1f/fCol2alpha1-cre) mice exhibited impaired cartilage formation, decre...
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#1Zizheng Dong (UT: University of Toledo)
#2Jianguo Liu (UT: University of Toledo)
Last. Jian-Ting Zhang (UT: University of Toledo)
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eIF3a is a putative subunit of the eukaryotic translation initiation factor 3 complex. Accumulating evidence suggests that eIF3a may have a translational regulatory function by suppressing translation of a subset of mRNAs while accelerating that of other mRNAs. Albeit the suppression of mRNA translation may derive from eIF3a binding to the 5'-UTRs of target mRNAs, how eIF3a may accelerate mRNA translation remains unknown. In this study, we show that eIF3a up-regulates translation of Chk1 but not...
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#1Ritika Kabra (National Center for Charitable Statistics)
#2Prajakta Ingale (National Center for Charitable Statistics)
Last. Shailza Singh (National Center for Charitable Statistics)H-Index: 2
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Emergence of drug resistance is major concern for combating against Cutaneous Leishmaniasis, a neglected tropical disease affecting 98 countries including India. Miltefosine is the only oral drug available for the disease and Miltefosine transporter proteins play pivotal role in the emergence of drug resistant Leishmania major. The cause of resistance is less accumulation of drug inside the parasite either by less uptake of drug due to decrease in the activity of P4ATPase-CDC50 complex or by inc...
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#1Jeppe Kari (DTU: Technical University of Denmark)H-Index: 7
#2Corinna Schiano-di-Cola (RU: Roskilde University)H-Index: 2
Last. Peter Westh (DTU: Technical University of Denmark)H-Index: 37
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Kinetic theory of enzymes that modify insoluble substrates is still underdeveloped, despite the prevalence of this type of reaction both in vivo and industrial applications. Here, we present a steady-state kinetic approach to investigate inhibition occurring at the solid-liquid interface. We propose to conduct experiments under enzyme excess (E0>>S0), i.e. the opposite limit compared to the conventional Michaelis-Menten framework. This inverse condition is practical for insoluble substrates and ...
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