AGA Clinical Practice Update on Colorectal and Pancreatic Cancer Risk and Screening in BRCA1 and BRCA2 Carriers: Commentary

Genetic testing for hereditary cancer syndromes is becoming increasingly common. Carriers of BRCA1 or BRCA2 pathogenic variants (ie, mutations) are among the most commonly identified in hereditary cancer risk assessment. BRCA1 and BRCA2 encode proteins involved in homologous recombination and double-stranded DNA break repair. Germline pathogenic variants in BRCA1 and BRCA2 are highly penetrant for breast cancer and ovarian cancer, conferring...