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Gastroenterology
IF
19.23
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111512
Papers 111110
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Abstract: Background & Aims Irritable bowel syndrome (IBS) is a heterogeneous disorder but diagnoses and determination of sub-types are made based on symptoms. We profiled fecal microbiomes of patients with and without irritable bowel syndrome (IBS) to identify biomarkers of this disorder. Methods We collected fecal and urine samples from 80 patients with IBS (Rome IV criteria; 16–70 years old) and 65 matched individuals without IBS (controls), along with anthropometric, medical, and dietary inf...
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Abstract Background & Aims Pancreatic ductal adenocarcinoma (PDAC) is associated with the highest incidence of venous thromboembolism (VTE) of any cancer type. However, little is known about risk factors for VTE or its outcomes in patients with PDAC. Methods We collected data from a prospective, observational study performed at multiple centers in France from May 2014 through November 2018 (the Base Clinico-Biologique de l’Adenocarcinome Pancreatique [BACAP] study) linked to a database of patien...
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Abstract Background & Aims Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy that invades surrounding structures and metastasizes rapidly. Although inflammation is associated with tumor formation and progression, little is known about the mechanisms of this connection. We investigate the effects of interleukin 22 (IL22) in development of pancreatic tumors in mice. Methods We performed studies with Pdx1-Cre;LSL-KrasG12D;Trp53+/-;Rosa26EYFP/+ (PKCY) mice, which develop pancreatic...
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Abstract Background Aims Trehalose is a disaccharide that might be used in treatment of cardiometabolic diseases. However, trehalose consumption promotes expansion of Clostridioides difficile ribotypes that metabolize trehalose via trehalose-6-phosphate hydrolase (treA). Furthermore, brush border and renal trehalases can reduce the efficacy of trehalose by cleaving it into monosaccharides. We investigated whether a trehalase-resistant analogue of trehalose (lactotrehalose) has the same metabolic...
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#1Jordan Shapiro (BCM: Baylor College of Medicine)H-Index: 1
#2Hashem B. El-Serag (BCM: Baylor College of Medicine)H-Index: 101
Last.Johanna Chan (BCM: Baylor College of Medicine)H-Index: 1
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Top fields of study
Endocrinology
Diabetes mellitus
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Gastroenterology