Supersaturated-Silica Lipid Hybrids Improve in Vitro Solubilization of Abiraterone Acetate
Abstract
Abiraterone acetate (AbA) is a poorly water-soluble drug with an oral bioavailability of <10% and a significant pharmaceutical food effect. We aimed to develop a more efficient oral solid-state lipid-based formulation for AbA using a supersaturated silica-lipid hybrid (super-SLH) approach to achieve high drug loading, improve in vitro solubilization and mitigate the food effect, while gaining a mechanistic insight into how super-SLH are digested...
Paper Details
Title
Supersaturated-Silica Lipid Hybrids Improve in Vitro Solubilization of Abiraterone Acetate
Published Date
Mar 31, 2020
Journal
Volume
37
Issue
4
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