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Clive A. Prestidge
University of South Australia
AdsorptionOrganic chemistryInorganic chemistryChemistryChromatography
231Publications
39H-index
4,952Citations
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Publications 241
Newest
#1Paul Joyce (UniSA: University of South Australia)H-Index: 8
#2Tahlia R. Meola (UniSA: University of South Australia)H-Index: 2
Last. Clive A. Prestidge (UniSA: University of South Australia)H-Index: 39
view all 4 authors...
Abstract Background Obesity is a rapidly growing concern worldwide, with over one-third of the global population classified as overweight or obese. While significant research has focused on developing new and improved nutritional and dietary approaches for regulating energy intake, there has been little success in overcoming the rising obesity statistics. Consequently, increasing attention is being afforded to designing safe, inexpensive and highly efficacious food-based materials that control f...
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#1Caroline Alvebratt (Uppsala University)H-Index: 2
#2Tahnee J. Dening (UniSA: University of South Australia)H-Index: 6
Last. Christel A. S. Bergström (Uppsala University)H-Index: 30
view all 8 authors...
Lipid-based formulations can circumvent the low aqueous solubility of problematic drug compounds and increase their oral absorption. As these formulations are often physically unstable and costly to manufacture, solidification has been suggested as a way to minimize these issues. This study evaluated the physicochemical stability and in vitro performance of lipid-loaded mesoporous magnesium carbonate (MMC) particles with an average pore size of 20 nm. A medium chain lipid was loaded onto the MMC...
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#1Ludivine C. Delon (UniSA: University of South Australia)H-Index: 1
#2Azadeh Nilghaz (UniSA: University of South Australia)H-Index: 13
Last. Benjamin Thierry (UniSA: University of South Australia)H-Index: 26
view all 5 authors...
Microfluidic organs-on-chips are rapidly being developed toward eliminating the shortcomings of static in vitro models and better addressing basic and translational research questions. A critical aspect is the dynamic culture environment they provide. However, the associated inherent requirement for controlled fluid shear stress (FSS) and therefore the need for precise pumps limits their implementation. To address this issue, here a novel approach to manufacture pumpless and tubeless organs-on-c...
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#1Paul Joyce (Chalmers University of Technology)H-Index: 8
#2Hanna Ulmefors (UniSA: University of South Australia)H-Index: 1
Last. Clive A. Prestidge (UniSA: University of South Australia)H-Index: 39
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An urgent demand exists for the development of novel delivery systems that efficiently transport antibacterial agents across cellular membranes for the eradication of intracellular pathogens. In this study, the clinically relevant poorly water-soluble antibiotic, rifampicin, was confined within mesoporous silica nanoparticles (MSN) to investigate their ability to serve as an efficacious nanocarrier system against small colony variants of Staphylococcus aureus (SCV S. aureus) hosted within Caco-2...
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#1Mitja Pohlen (University of Ljubljana)H-Index: 1
#2Zoran Lavrič (University of Ljubljana)H-Index: 7
Last. Rok Dreu (University of Ljubljana)H-Index: 15
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In the presented study, insight into the development and optimisation of the dry emulsion formulation and spray drying process is provided. The aim was to facilitate the dissolution of the poorly soluble, highly lipophilic drug, simvastatin, by forming spray-dried dry emulsion particles having adequate powder flow properties, while assuring sufficient drug content. Simvastatin and a mixture of caprylic, capric triglyceride and 1-oleoyl-rac-glycerol were employed as a model drug and solubilising ...
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#1Hayley B. Schultz (UniSA: University of South Australia)H-Index: 2
#2Anthony Wignall (UniSA: University of South Australia)H-Index: 3
Last. Clive A. Prestidge (UniSA: University of South Australia)H-Index: 39
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Abstract Abiraterone acetate (AbA) has an oral bioavailability of An oral pharmacokinetic study was conducted in fasted Sprague-Dawley rats. Suspensions of the formulations were administered via oral gavage at an AbA dose of 25 mg/kg. Plasma samples were collected and analyzed for drug content. SLH with a saturation level of 90% Seq enhanced the oral bioavailability of unformulated AbA by 31-fold, and super-SLH with saturation levels of 150, 200 and 250% Seq, enhanced the bioavailability by 11, ...
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#1Hayley B. Schultz (UniSA: University of South Australia)H-Index: 2
#2Paul Joyce (UniSA: University of South Australia)H-Index: 8
Last. Clive A. Prestidge (UniSA: University of South Australia)H-Index: 39
view all 4 authors...
PURPOSE: Abiraterone acetate (AbA) is a poorly water-soluble drug with an oral bioavailability of <10% and a significant pharmaceutical food effect. We aimed to develop a more efficient oral solid-state lipid-based formulation for AbA using a supersaturated silica-lipid hybrid (super-SLH) approach to achieve high drug loading, improve in vitro solubilization and mitigate the food effect, while gaining a mechanistic insight into how super-SLH are digested and release drug. METHODS: The influence ...
1 CitationsSource
#1Paul JoyceH-Index: 8
#2Hanna UlmeforsH-Index: 1
Last. Clive A. PrestidgeH-Index: 39
view all 4 authors...
Understanding lipase-mediated hydrolysis mechanisms within solid-state nanocarriers is fundamental for the rational design of lipid-based formulations. In this study, SBA-15 ordered mesoporous silica (MPS) particles were engineered with well-controlled nanostructural properties to systematically elucidate the role of intrawall microporosity, mesopore size and particle structure on lipase activity. Microporosity and diffusional path length were shown to be key modulators for lipase-provoked hydro...
1 CitationsSource
#1Chelsea R. Thorn (UniSA: University of South Australia)H-Index: 1
#2Andrew J. Clulow (Monash University)H-Index: 9
Last. Nicky Thomas (UniSA: University of South Australia)H-Index: 13
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Abstract In the advent of the post-antibiotic era, new strategies are urgently required to improve the efficacy of antimicrobials and outsmart multi-drug resistant bacteria. Exploiting a basic survival mechanism of bacteria, lipase production, monoolein liquid crystal nanoparticles (MO-LCNP) were investigated as a bacterial-triggered drug delivery system for three different antimicrobial compounds and compared with model sn-1/3 regiospecific and non-regiospecific lipases via pH-stat titration, p...
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Candida albicans (C. albicans) is a common fungal pathogen causing both localised and systemic infections. The majority of these infections are promoted by biofilm formation, providing a protective matrix for the embedded fungi thereby evading the host immune defence and promoting resistance against anti-mycotic agents. In this study, pH-responsive micellar systems based on poly-(ethylene glycol) ethyl ether methacrylate (PEGMA) and poly 2-(diethylamino) ethyl methacrylate (DEAEMA) block-copolym...
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