Pharmaceutical Research
Papers 8922
1 page of 893 pages (8,922 results)
#1Liang Zheng (Sichuan University)H-Index: 1
#2Miao Xu (Sichuan University)
Last.Ling Wang (Sichuan University)H-Index: 10
view all 6 authors...
Purpose Physiologically-based pharmacokinetic (PBPK) modeling offers a unique modality to predict age-specific pharmacokinetics. The objective of this study was to assess the ability of PBPK model to predict plasma exposure of oxycodone, a widely used opioid for pain management, in adults and children.
#1Songtao LiH-Index: 1
#2Hongling ZhaoH-Index: 1
view all 10 authors...
#1Mohammad Azad (MIT: Massachusetts Institute of Technology)H-Index: 9
#2Juan G. Osorio (MIT: Massachusetts Institute of Technology)H-Index: 8
Last.Allan S. Myerson (MIT: Massachusetts Institute of Technology)H-Index: 45
view all 11 authors...
Purpose Oral direct compressible tablets are the most frequently used drug products. Manufacturing of tablets requires design and development of formulations, which need a number of excipients. The choice of excipients depends on the concentration, manufacturability, stability, and bioavailability of the active pharmaceutical ingredients (APIs). At MIT, we developed a miniature platform for on-demand manufacturing of direct compressible tablets. This study investigated how formulations could be ...
#1Marie-Rose B. S. Crombag (NKI-AVL: Netherlands Cancer Institute)H-Index: 2
#2Stijn L.W. Koolen (EUR: Erasmus University Rotterdam)H-Index: 7
Last.Alwin D. R. Huitema (NKI-AVL: Netherlands Cancer Institute)H-Index: 41
view all 9 authors...
Purpose There is ongoing concern regarding increased toxicity from paclitaxel in elderly patients, particularly of severe neutropenia. Yet, data so far is controversial and this concern is not supported by a clinically relevant age-dependent difference in pharmacokinetics (PK) of paclitaxel. This study assessed whether age is associated with increased risk for paclitaxel-induced neutropenia.
#1Christoph Gesenberg (BMS: Bristol-Myers Squibb)H-Index: 5
#2Neil R. Mathias (BMS: Bristol-Myers Squibb)H-Index: 13
Last.Jatin M. Patel (BMS: Bristol-Myers Squibb)H-Index: 1
view all 13 authors...
Purpose To describe a stepwise approach to evaluate the pH effect for a weakly basic drug by in vitro, in vivo and in silico techniques and identify a viable mitigation strategy that addresses the risk.
#1Liang Zhu (Pfizer)
#2Ying Wang (Pfizer)
Last.Boris Gorovits (Pfizer)H-Index: 18
view all 5 authors...
Purpose The purpose of this study was to validate a ligand binding assay for the quantitation of a monoclonal antibody-based biotherapeutics (PF-57781346) in samples collected via capillary microsampling to support a regulated mouse toxicity study.
#1Aliyeh Ghamkhari (PNU: Payame Noor University)H-Index: 5
#2Ayda Pouyafar (Tabriz University of Medical Sciences)H-Index: 3
Last.Reza Rahbarghazi (Tabriz University of Medical Sciences)H-Index: 13
view all 4 authors...
Purpose Cancer stem cells (CSCs) have been suggested to represent the main cause of tumour progression, metastasis and drug resistance. Therefore, these cells can be an appropriate target to improve cancer treatment.
#1Nicholas G. Lamson (CMU: Carnegie Mellon University)H-Index: 2
#2Rebecca L. Ball (CMU: Carnegie Mellon University)H-Index: 5
Last.Kathryn A. Whitehead (CMU: Carnegie Mellon University)H-Index: 18
view all 4 authors...
Purpose Caco-2 monolayers are the most common model of the intestinal epithelium and are critical to the development of oral drug delivery strategies and gastrointestinal disease treatments. However, current monolayer systems are cost- and/or time-intensive, hampering progress. This study evaluates two separate methods to reduce resource input: FB Essence as a fetal bovine serum (FBS) alternative and a new, 3-day Caco-2 system deemed “thrifty, rapid intestinal monolayers” (TRIM).
#1Alexander Kalies (UHH: University of Hamburg)H-Index: 1
#2Hüseyin ÖzcobanH-Index: 11
Last.Claudia S. Leopold (UHH: University of Hamburg)H-Index: 20
view all 3 authors...
Purpose In the present study the influence and application of a newly developed external lower punch vibration system for an improved die filling on a running rotary tablet press was investigated.
#1Miriam Braunstein (UNC: University of North Carolina at Chapel Hill)H-Index: 24
#2Anthony J. Hickey (UNC: University of North Carolina at Chapel Hill)H-Index: 45
Last.Sean Ekins (UNC: University of North Carolina at Chapel Hill)
view all 3 authors...
The discovery of drugs to treat tuberculosis (TB) was a major medical milestone in the twentieth century. However, from the outset, drug resistance was observed. Currently, of the 10 million people that exhibit TB symptoms each year, 450,000 have multidrug or extensively drug resistant (MDR or XDR) TB. While greater understanding of the host and pathogen (Mycobacterium tuberculosis, Mtb) coupled with scientific ingenuity will lead to new drugs and vaccines, in the meantime 4000 people die daily ...
Top fields of study