Pharmaceutical Research
Papers 9035
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#1Cao Dai Phung (Yeungnam University)H-Index: 4
#2Thien Giap Le (Hanoi University)
Last. Chien Ngoc Nguyen (Hanoi University)H-Index: 6
view all 8 authors...
PURPOSE Development of a nanoplatform constructed by the PEG-dual drug conjugation for co-delivery of paclitaxel (PTX) and Dihydroartemisinin (DHA) to the tumor. METHODS PEG was conjugated with PTX and DHA to form PTX-PEG-DHA complex as a nanocarrier. The PTX and DHA were co-encapsulated in PTX-PEG-DHA nanoparticles (PD@PPD NPs) by the emulsion evaporation method. The physicochemical properties of PD@PPD Nps were characterized, including size, zeta potential, and morphology. The drug loading cap...
#1Ira Shrestha (Yeungnam University)
#2Jong Soo Choi (Yeungnam University)H-Index: 6
Last. Kyung-Oh Doh (Yeungnam University)H-Index: 8
view all 4 authors...
PURPOSE Efficient and safe vehicle that can enhance gene transfer is still needed. Since intracellular cholesterol is known to have an important role in gene delivery and itraconazole alters intracellular cholesterol trafficking, we investigated the effect of itraconazole on pDNA and siRNA delivery. METHODS The pDNA and Bcl2 siRNA transfection efficiency was measured by luciferase assay and cytotoxicity. Cellular cholesterol was observed using filipin staining, and intracellular uptake was analy...
#1T.P. Tim Cushnie (MSU: Mahasarakham University)H-Index: 13
#2Benjamart Cushnie (MSU: Mahasarakham University)H-Index: 2
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Bioprospecting is the exploration, extraction and screening of biological material and sometimes indigenous knowledge to discover and develop new drugs and other products. Most antibiotics in current clinical use (eg. β-lactams, aminoglycosides, tetracyclines, macrolides) were discovered using this approach, and there are strong arguments to reprioritize bioprospecting over other strategies in the search for new antibacterial drugs. Academic institutions should be well positioned to lead the ear...
#1Sean EkinsH-Index: 59
#2Ana C. PuhlH-Index: 2
Last. Audrey Davidow (University of Pittsburgh)H-Index: 1
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Individuals with the rare genetic disorder Pitt Hopkins Syndrome (PTHS) do not have sufficient expression of the transcription factor 4 (TCF4) which is located on chromosome 18. TCF4 is a basic helix-loop-helix E protein that is critical for the normal development of the nervous system and the brain in humans. PTHS patients lacking sufficient TCF4 frequently display gastrointestinal issues, intellectual disability and breathing problems. PTHS patients also commonly do not speak and display disti...
#1Jeffry Adiwidjaja (USYD: University of Sydney)H-Index: 1
#2Alan V. Boddy (UniSA: University of South Australia)H-Index: 37
Last. Andrew J. McLachlan (USYD: University of Sydney)H-Index: 50
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This study aimed to investigate the potential pharmacokinetic interactions between curcumin, imatinib and bosutinib, combining In Vitro and in silico methods. In Vitro metabolism of imatinib and bosutinib were investigated in pooled human liver microsomes and recombinant CYP3A4 enzyme in the presence and absence of curcumin and curcumin glucuronide using an LC-MS/MS assay for N-desmethyl metabolites. A physiologically-based pharmacokinetic (PBPK) model for curcumin formulated as solid lipid nano...
#1Niklas J. Koehl (UCC: University College Cork)H-Index: 3
#2René Holm (Johnson & Johnson)H-Index: 30
Last. Brendan T. Griffin (UCC: University College Cork)H-Index: 19
view all 4 authors...
Lipid-based formulations (LBF) have shown oral bioavailability enhancement of lipophilic drugs, but not necessarily in the case of hydrophobic drugs. This study explored the potential of lipid vehicles to improve the bioavailability of the hydrophobic drug nilotinib comparing a chase dosing approach and lipid suspensions. Nilotinib in vivo bioavailability in rats was determined after administering an aqueous suspension chase dosed with blank olive oil, Captex 1000, Peceol or Capmul MCM, respecti...
#1Mauricio García (UC: Pontifical Catholic University of Chile)H-Index: 3
#1Mauricio A. García (University of Mainz)
Last. Pablo M. GonzálezH-Index: 4
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PURPOSE MDCK cells are commonly used to assess drug permeability, but the existence of various strains merits a comparative functional study. Since metformin absorption is largely mediated by transporters and paracellular diffusion, we used it to functionally compare MDCK-wt and MDCK-II. METHODS Uptake, bidirectional transport and efflux experiments were performed using different buffers, pH, and a panel of transporter inhibitors. Relative contributions to total transport in both strains were es...
#1Kento Takamura (Osaka University)
#2Keisuke Tachibana (Osaka University)H-Index: 12
Last. Masuo Kondoh (Osaka University)H-Index: 33
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Dossiers on approved pharmaceutical products must be kept updated and current during the products' life cycles. The coalition, merger and acquisition along with corporate strategy that pursues efficiency and profitability of pharmaceutical companies have led to the globalization of supply chains for pharmaceutical ingredients and instruments in the post-marketing phase, and progress in manufacturing technologies can improve manufacturing processes during this phase. Regulatory requirements for p...
#1Vineela Parvathaneni (St. John's University)H-Index: 1
#2Mimansa Goyal (St. John's University)
Last. Vivek Gupta (St. John's University)H-Index: 21
view all 5 authors...
PURPOSE Nelfinavir (NFV), a FDA approved antiretroviral drug, has been reported to exhibit cancer cells growth inhibition and increased apoptosis. However, it requires a higher dose leading to toxicity, thus limiting its potential clinical translation. We aim to develop biodegradable (poly (lactic-co-glycolic acid)) PLGA nanoparticles of nelfinavir and determine their efficacy to treat non-small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN HIV protease inhibitor, NFV, was loaded into PLGA nanop...
#1Arne Staby (Novo Nordisk)H-Index: 18
#2Dorte Bjerre Steensgaard (Novo Nordisk)H-Index: 11
Last. Désirée J. Asgreen (Novo Nordisk)
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PURPOSE Manufacturing processes for polypeptide/protein drugs are designed to ensure robust quality, efficacy and safety. Process differences introduced by follow-on manufacturers may result in changes in quality and clinical outcomes. This study investigated the impact of production methods on the stability and impurities of liraglutide and semaglutide drug substances/products, and the potential impact on drug quality, efficacy and safety. METHODS State-of-the-art analytical methods were used t...
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