Molecular Regulation of Polycystin TRP Channels

Autosomal dominant polycystic kidney disease (ADPKD) causes progressive renal failure and can be caused by variants in the PKD2 genes which encode the polycystin-2 transient receptor ion channel (TRP). Despite our strong understanding of the genetic basis of ADPKD, we still do not know how polycystin-2 ion channel function is molecularly regulated. This basic question remains outstanding because polycystin-2 localizes to primary cilium—an...