Biophysical Journal
Papers 62081
1 page of 6,209 pages (62.1k results)
#1Barak Gilboa (University of Oxford)
#2Bo Jing (University of Oxford)H-Index: 1
Last.Achillefs N. Kapanidis (University of Oxford)H-Index: 36
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Abstract Single-molecule fluorescence has been highly instrumental in elucidating interactions and dynamics of biological molecules in the past two decades. Single-molecule fluorescence experiments usually rely on one of two detection geometries, either confocal point-detection or wide-field area detection, typically in a total internal reflection illumination fluorescence (TIRF) format. However, each of these techniques suffers from fundamental drawbacks that limit their application. In this wo...
#2Daniel Lobo (UMBC: University of Maryland, Baltimore County)H-Index: 13
Abstract Cell-cell adhesion is essential for tissue growth and multicellular pattern formation, and crucial for the cellular dynamics during embryogenesis and cancer progression. Understanding the dynamical gene regulation of cell adhesion molecules (CAMs) responsible for the emerging spatial tissue behaviors is a current challenge due to the complexity of these non-linear interactions and feedback loops at different levels of abstraction—from genetic regulation to whole-organism shape formation...
#1Michael A. Kelley (Colorado School of Mines)
#2Karin Leiderman (Colorado School of Mines)H-Index: 11
Abstract Thrombin plays many important roles in the blood clotting process; it activates platelets, cleaves coagulation proteins within feedback loops, and cleaves fibrinogen into fibrin, which polymerizes into fibers to form a stabilizing gel matrix in and around growing clots. Thrombin also binds to the formed fibrin matrix but this interaction is not well understood. Thrombin-fibrin binding is typically described as two independent, single-step binding events, one high- and one low-affinity. ...
#1Ying Zhang (BU: Boston University)H-Index: 1
#2Lara Clemens (UCI: University of California, Irvine)H-Index: 2
Last.Samuel A. Isaacson (BU: Boston University)H-Index: 11
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Abstract Signalling by surface receptors often relies on tethered reactions whereby an enzyme bound to the cytoplasmic tail of a receptor catalyses reactions on substrates within reach. The overall length and stiffness of the receptor tail, the enzyme, and the substrate determine a biophysical parameter termed the molecular reach of the reaction. This parameter determines the probability that the receptor-tethered-enzyme will contact the substrate, in the volume proximal to the membrane, when se...
#1Xiaohu Hu (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 1
#2Davide Provasi (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 20
Last.Marta Filizola (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 35
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Abstract In the era of opioid abuse epidemics, there is an increased demand for understanding how opioid receptors can be allosterically modulated to guide the development of more effective and safer opioid therapies. Among the modulators of the μ-opioid (MOP) receptor, which is the pharmacological target for the majority of clinically used opioid drugs, are monovalent and divalent cations. Specifically, the monovalent sodium cation (Na+) has been known for decades to affect MOP receptor signali...
#1Abdallah I. Hasaballa (University of Auckland)H-Index: 1
#2Vicky Y. Wang (University of Auckland)H-Index: 8
Last.Martyn P. Nash (University of Auckland)H-Index: 35
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Abstract Heart failure (HF) is one of the leading causes of death worldwide. HF is associated with substantial microstructural remodeling, which is linked to changes in left ventricular geometry and impaired cardiac function. The role of myocardial remodeling in altering the mechanics of failing hearts remains unclear. Structurally-based constitutive modeling provides an approach to improve understanding of the relationship between biomechanical function and tissue organization in cardiac muscle...
#1James Holehouse (Edin.: University of Edinburgh)H-Index: 1
#2Ramon Grima (Edin.: University of Edinburgh)H-Index: 29
Abstract Propensity functions of the Hill-type are commonly used to model transcriptional regulation in stochastic models of gene expression. This leads to an effective reduced master equation for the mRNA and protein dynamics only. Based on deterministic considerations, it is often stated or tacitly assumed that such models are valid in the limit of rapid promoter switching. Here, starting from the chemical master equation describing promoter-protein interactions, mRNA transcription, protein tr...
1 CitationsSource
#1Ishrat Jahan (AMU: Aligarh Muslim University)H-Index: 2
#2Shahid M. Nayeem (AMU: Aligarh Muslim University)H-Index: 3
Abstract α-synuclein is an intrinsically disordered protein (IDP) whose function in healthy brain is poorly understood. It is genetically and neuropathologically linked to Parkinson’s disease (PD). PD is manifested after accumulation of plaques of α-synuclein aggregates in the brain cells. Aggregates of α-synuclein are very toxic and lead to the disruption of cellular homeostasis and neuronal death. α-synuclein can also contribute to disease propagation as it may exert noxious effects on neighbo...
#1Ranit Gruber (Weizmann Institute of Science)H-Index: 4
#2Tridib Mondal (Weizmann Institute of Science)H-Index: 1
Last.Amnon Horovitz (Weizmann Institute of Science)H-Index: 33
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Abstract A fundamental problem that has hindered the use of the classic Monod-Wyman-Changuex (MWC) allosteric model since its introduction is that it has been difficult to determine the values of its parameters in a reliable manner since they are correlated with each other and sensitive to the data fitting method. Consequently, experimental data are often fitted to the Hill equation, which provides a measure of cooperativity but no insights into its origin. In this work, we derived a general rel...
1 CitationsSource
#1Liliya Vugmeyster (University of Colorado Denver)H-Index: 12
#2Dan F. Au (University of Colorado Denver)
Last.Wei Qiang (Binghamton University)H-Index: 17
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Abstract We investigate the variability in the dynamics of the disordered N-terminal domain of amyloid-β fibrils (Aβ), comprising residues 1–16 of Aβ1–40, due to post-translational modifications and mutations in the β-bend regions known to modulate aggregation properties. Using 2H static solid-state NMR approaches, we compare the dynamics in the wild-type Aβ fibrils in the threefold symmetric polymorph with the fibrils from three post-translational modification sequences: isoaspartate-D7, the ph...
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