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Biophysical Journal
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#1Xiangze Zeng (WashU: Washington University in St. Louis)H-Index: 4
#2Alex S. Holehouse (WashU: Washington University in St. Louis)H-Index: 14
Last. Rohit V. Pappu (WashU: Washington University in St. Louis)H-Index: 46
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Abstract Phase separation is thought to underlie spatial and temporal organization that is required for controlling biochemical reactions in cells. Multivalence of interaction motifs also known as stickers is a defining feature of proteins that drive phase separation. Intrinsically disordered proteins with stickers uniformly distributed along the linear sequence can serve as scaffold molecules that drive phase separation. The sequence-intrinsic contributions of disordered proteins to phase separ...
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#1Charalampos Kapsalis (St And: University of St Andrews)H-Index: 1
#2Y. Ma (University of Leeds)
Last. Christos Pliotas (St And: University of St Andrews)H-Index: 8
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Abstract The mechanosensitive channel of large conductance (MscL) from Mycobacterium tuberculosis has been used as structural model for rationalizing functional observations in multiple MscL orthologues. Although these orthologues adopt similar structural architectures, they reportedly present significant functional differences. Subtle structural discrepancies on mechanosensitive channel nano-pockets are known to affect mechanical gating and may be linked to large variability in tension sensitiv...
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Chemistry
Membrane
Biochemistry
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