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Paul G. DeCaen
Northwestern University
45Publications
20H-index
1,783Citations
Publications 50
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#1Thuy N. VienH-Index: 5
Last.Paul G. DeCaenH-Index: 20
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#1Paul G. DeCaen (CNRS: Centre national de la recherche scientifique)H-Index: 20
#2Agnès Rolland-Sabaté (INRA: Institut national de la recherche agronomique)H-Index: 19
Last.Eric M. Leroy (CNRS: Centre national de la recherche scientifique)H-Index: 55
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Abstract Maize starch was plasticized by glycerol, choline chloride ([Chol][Cl]) and ionic liquids (Choline acetate ([Chol][Ace]), 1-Ethyl-3-methylimidazolium Chloride ([EMIM][Cl]) and 1-Ethyl-3-methylimidazolium acetate ([EMIM][Ace]). Melt rheology at 120 °C was assessed with a twin-screw micro-compounder used for processing small quantities (8-10 g), and with a capillary rheometer with pre-shearing (Rheoplast). Qualitative agreement was found between shear viscosities obtained by both rheometr...
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#1Geancarlo Zanatta (Lond: University of London)
#2Altin Sula (Lond: University of London)H-Index: 6
Last.Bonnie A. Wallace (Lond: University of London)H-Index: 53
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Valproic acid (VPA) is an anticonvulsant drug that is also used to treat migraines and bipolar disorder. Its proposed biological targets include human voltage-gated sodium channels, among other membrane proteins. We used the prokaryotic NavMs sodium channel, which has been shown to be a good exemplar for drug binding to human sodium channels, to examine the structural and functional interactions of VPA. Thermal melt synchrotron radiation circular dichroism spectroscopic binding studies of the fu...
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#1L.C.T. NgH-Index: 1
#2Leo C.T. NgH-Index: 1
Last.Paul G. DeCaenH-Index: 20
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#1Vladimir Yarov-Yarovoy (UC Davis: University of California, Davis)H-Index: 35
#2Paul G. DeCaen (NU: Northwestern University)H-Index: 20
Voltage-gated sodium channels (Navs) initiate the action potential waveforms in excitable cells. The molecular mechanisms controlling this process have been actively debated. New prokaryotic Nav structures by Wisedchaisri et al . have completed our understanding of the molecular conformations required for cellular electrical signaling, and provide key templates for research to examine eukaryotic Navs.
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#1Nathaniel T. BlairH-Index: 11
#2Ingrid CarvachoH-Index: 7
Last.Michael X. ZhuH-Index: 53
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#1Leo C.T. Ng (NU: Northwestern University)H-Index: 1
#2Thuy N. Vien (NU: Northwestern University)H-Index: 5
Last.Paul G. DeCaen (NU: Northwestern University)H-Index: 20
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The opening of voltage-gated ion channels is initiated by transfer of gating charges that sense the electric field across the membrane. Although transient receptor potential ion channels (TRP) are members of this family, their opening is not intrinsically linked to membrane potential, and they are generally not considered voltage gated. Here we demonstrate that TRPP2, a member of the polycystin subfamily of TRP channels encoded by the PKD2L1 gene, is an exception to this rule. TRPP2 borrows a bi...
1 CitationsSource
#1Cheng TangH-Index: 4
#2Xi ZhouH-Index: 5
Last.Songping LiangH-Index: 34
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#1Leo C.T. NgH-Index: 1
#2Thuy N. VienH-Index: 5
Last.Paul G. DeCaenH-Index: 20
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#2Leo C.T. NgH-Index: 1
Last.Paul G. DeCaenH-Index: 20
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