Automated Fiber Diameter and Porosity Measurement of Fibrin Clots in SEM Images

SEM images of fibrin meshes can provide profound insights into the microstructure of blood clots. This is significant because characteristics of clot microstructure, such as fiber diameter and clot porosity, may be altered in disease (e.g., cardiovascular disease) and by other factors (e.g., medications). In the past, SEM images of fibrin clots were analyzed manually - a burdensome and bias-prone process, in which a user inspects images and...