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Martin Guthold
Wake Forest University
ChemistryFiberFibrinDNABiology
101Publications
29H-index
4,033Citations
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Publications 102
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#1Hyunsu Lee (Wake Forest University)H-Index: 3
#2Keith Bonin (Wake Forest University)H-Index: 19
Last. Martin Guthold (Wake Forest University)H-Index: 29
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The epithelium forms a protective barrier against external biological, chemical and physical insults. So far, AFM-based, micro-mechanical measurements have only been performed on single cells and confluent cells, but not yet on cells in the physiologically relevant, mature epithelial layer. Using a combination of atomic force, fluorescence and confocal microscopy, we determined the changes in stiffness, morphology and actin distribution of human mammary epithelial cells (HMECs) as they transitio...
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#1Hyunsu LeeH-Index: 3
#1Hyun-Su LeeH-Index: 10
Last. Martin GutholdH-Index: 29
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#2Marlien PietersH-Index: 16
Last. Martin GutholdH-Index: 29
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#1Marlien Pieters (NWU: North-West University)H-Index: 16
#2Martin Guthold (Wake Forest University)H-Index: 29
Last. Zelda de Lange (NWU: North-West University)H-Index: 6
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Turbidimetry is used to characterize fibrin clot properties. In purified systems, maximum absorbance (MA) directly relates to fibrin fiber cross-sectional area. However, in plasma samples there are discrepancies in the relationships between MA and fibrinogen concentration, fiber diameter, other clot properties, and cardiovascular disease outcomes, which complicate data interpretation. This study aims to advance understanding of MA of plasma clots through testing how well it relates to fundamenta...
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#1Kelli Simms (Wake Forest University)
#2Elisabeth Rebholz (Wake Forest University)
Last. Elaheh Rahbar (Wake Forest University)H-Index: 13
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Red blood cell (RBC) hemolysis is one of the most common storage lesions in packed RBCs (pRBC). Older units of pRBCs, especially those > 21 days old, have increasing levels of hemolysis leading to increased oxidative stress and premature platelet activation. This effect can mostly be attributed to the increase of cell-free hemoglobin (Hb). Therefore, removal of cell-free Hb from pRBCs prior to transfusion could mitigate these deleterious effects. We propose a new method for the removal of Hb fro...
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#1Nadeem Wajih (Wake Forest University)H-Index: 14
#2Swati Basu (Wake Forest University)H-Index: 18
Last. Daniel B. Kim-Shapiro (Wake Forest University)H-Index: 39
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Abstract Background Nitrite is reduced by heme-proteins and molybdenum-containing enzymes to form the important signaling molecule nitric oxide (NO), mediating NO signaling. Substantial evidence suggests that deoxygenated hemoglobin within red blood cells (RBCs) is the main erythrocytic protein responsible for mediating nitrite-dependent NO signaling. In other work, infrared and far red light have been shown to have therapeutic potential that some attribute to production of NO. Here we explore w...
1 CitationsSource
#1Andrew M. Zeidell (Wake Forest University)H-Index: 3
#2Colin Tyznik (Wake Forest University)H-Index: 1
Last. Oana D. Jurchescu (Wake Forest University)H-Index: 31
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8 CitationsSource
#1Zachary A. Lamport (Wake Forest University)H-Index: 5
#2Katrina J. Barth (Wake Forest University)H-Index: 4
Last. Oana D. Jurchescu (Wake Forest University)H-Index: 31
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Efficient injection of charge carriers from the contacts into the semiconductor layer is crucial for achieving high-performance organic devices. The potential drop necessary to accomplish this process yields a resistance associated with the contacts, namely the contact resistance. A large contact resistance can limit the operation of devices and even lead to inaccuracies in the extraction of the device parameters. Here, we demonstrate a simple and efficient strategy for reducing the contact resi...
14 CitationsSource
#1Samrat Dutta (Wake Forest University)H-Index: 5
#2Claudio Rivetti (University of Parma)H-Index: 23
Last. Martin Guthold (Wake Forest University)H-Index: 29
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4 CitationsSource
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