Original paper
Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus
Abstract
The recent emergence of Wuhan coronavirus (2019-nCoV) puts the world on alert. 2019-nCoV is reminiscent of the SARS-CoV outbreak in 2002 to 2003. Our decade-long structural studies on the receptor recognition by SARS-CoV have identified key interactions between SARS-CoV spike protein and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV. One of the goals...
Figures & Tables
FIG 1 Structural analysis of human ACE2 recognition by 2019-nCoV and SARS-CoV. (...
FIG 2 Spike phylogeny of representative -genus lineage b coronaviruses. The spik...
FIG 3 Sequence comparison of 2019-nCoV and SARS-CoV. (A) Sequence alignment of S...
FIG 4 Structural analysis of animal ACE2 recognition by 2019-nCoV and SARS-CoV. ...
Paper Details
Title
Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus
Published Date
Jan 31, 2020
Journal
Volume
94
Issue
7
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