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Journal of Virology
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Papers 46534
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#1Ross HartmanH-Index: 1
Last. Mark J. YoungH-Index: 57
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#1Xufang DengH-Index: 11
#2Yafang ChenH-Index: 4
Last. Susan C. BakerH-Index: 39
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Coronaviruses express a multifunctional papain-like protease, termed PLP2. PLP2 acts as a protease that cleaves the viral replicase polyprotein, and a deubiquitinating (DUB) enzyme which removes ubiquitin moieties from ubiquitin-conjugated proteins. Previous in vitro studies implicated PLP2 DUB activity as a negative regulator of the host interferon (IFN) response, but the role of DUB activity during virus infection was unknown. Here, we used X-ray structure-guided mutagenesis and functional stu...
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#1Chaya PatelH-Index: 1
#2Sean S.A. TaylorH-Index: 1
Last. David A. LeibH-Index: 23
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#1Abul HashemH-Index: 1
#2Fumie MaetaniH-Index: 1
Last. K. Tsukiyama-KoharaH-Index: 9
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#1Jackie E. MaharH-Index: 8
#2Mang ShiH-Index: 26
Last. Edward C. HolmesH-Index: 113
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#1Aaron VolkH-Index: 1
#2Matthew HackbartH-Index: 1
Last. Susan C. BakerH-Index: 39
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Coronaviruses encode multiple interferon antagonists that modulate the host response to virus replication. Here, we evaluated the host transcriptional response to infection with murine coronaviruses encoding independent mutations in one of two different viral antagonists: the deubiquitinase (DUB) within nonstructural protein 3 or the endoribonuclease (EndoU) within nonstructural protein 15. We used transcriptomics approaches to compare the scope and kinetics of the host response to the wild-type...
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#1Chunqiang MaH-Index: 1
#2Wei XuH-Index: 1
Last. Jianguo WuH-Index: 36
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Top fields of study
Viral replication
Molecular biology
Virology
Virus
Biology