Journal of Virology
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#1Fusheng SiH-Index: 5
#2Bingqing ChenH-Index: 1
Last. Zhen LiH-Index: 11
view all 7 authors...
Accessory genes occurring between the S and E genes of coronaviruses have been studied quite intensively during the last decades. In porcine epidemic diarrhea virus (PEDV) the only gene at this location, ORF3, encodes a 224-residues membrane protein shown to exhibit ion channel activity and to enhance virus production. However, little is known about its intracellular trafficking nor about its function during PEDV infection. In this study, two recombinant PEDVs were rescued by targeted RNA recomb...
#1Noton K. Dutta (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 25
#2Kaushiki Mazumdar (UMB: University of Maryland, Baltimore)H-Index: 1
Last. James Gordy (Johns Hopkins University)H-Index: 4
view all 3 authors...
During the current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS�CoV-2), there has been an unprecedented level of global collaboration that has led to a rapid characterization of SARS�CoV-2 ([1][1]) Its sequence shares 79 6%
#1Chengzhi Xu (Harbin Veterinary Research Institute)
#2Bangfeng Xu (Harbin Veterinary Research Institute)H-Index: 1
Last. Yan Chen (Harbin Veterinary Research Institute)H-Index: 8
view all 14 authors...
#1Mengxu Sun (CAU: China Agricultural University)H-Index: 2
#2Lijiao ZhangH-Index: 5
Last. Jingliang Su (CAU: China Agricultural University)H-Index: 8
view all 10 authors...
#1Thomas J. Kucharski (McGill University)H-Index: 4
#2Timothy F. Ng (McGill University)H-Index: 1
Last. Jose G. Teodoro (McGill University)H-Index: 22
view all 6 authors...
#1Kathy L. Poulin (Ottawa Hospital Research Institute)H-Index: 4
#2Emily McFall (Ottawa Hospital Research Institute)H-Index: 5
Last. Robin J. Parks (Ottawa Hospital Research Institute)H-Index: 31
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The human adenovirus (HAdV) protein IX (pIX) is a minor component of the capsid that acts in part to stabilize the hexon-hexon interactions within the mature capsid. Virions lacking pIX have a reduced DNA packaging capacity and exhibit thermal instability. More recently, pIX has been developed as a platform for presentation of large polypeptides, such as fluorescent proteins or large targeting ligands, on the viral capsid. It is not known if such modifications affect the natural ability of pIX t...
#1Xin Wei (Henan Agricultural University)
#2Rui LiH-Index: 8
Last. Gaiping Zhang (Henan Agricultural University)H-Index: 16
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Porcine reproductive and respiratory syndrome (PRRS), caused by PRRS virus (PRRSV), has led to enormous economic losses in global swine industry. Infection by PRRSV is previously shown to be via low pH-dependent clathrin-mediated endocytosis (CME) and CD163 functions as an essential receptor during viral infection. Despite much research focusing on it, PRRSV infection remains to be fully elucidated. In this study, we demonstrated that PRRSV externalized phosphatidylserine (PS) on the envelope as...
#1Kati Tormanen (Cedars-Sinai Medical Center)H-Index: 1
#2Shaohui Wang (Cedars-Sinai Medical Center)H-Index: 3
Last. Homayon Ghiasi (Cedars-Sinai Medical Center)H-Index: 31
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The immune modulatory protein Herpes virus entry mediator (HVEM) is one of several cellular receptors used by HSV-1 for cell entry. HVEM binds to HSV-1 glycoprotein D (gD) but is not necessary for HSV-1 replication in vitro or in vivo Previously we showed that although HSV-1 replication was similar in WT control and HVEM-/- mice, HSV-1 does not establish latency or reactivate effectively in mice lacking HVEM, suggesting that HVEM is important for these functions. It is not known whether HVEM imm...
#1Bryan S. Kaplan (ARS: Agricultural Research Service)H-Index: 2
#2J. Brian Kimble (ARS: Agricultural Research Service)
Last. Amy L. Vincent (ARS: Agricultural Research Service)H-Index: 41
view all 9 authors...
Influenza A viruses (IAV) sporadically transmit from swine to humans, typically associated with agricultural fairs in the USA. A human seasonal H3 from the 2010-2011 IAV season was introduced into the US swine population and termed H3.2010.1 to differentiate from the previous swine H3. This H3N2 lineage became widespread in the US commercial swine population, subsequently spilling over into exhibition swine, and caused a majority of H3N2 variant (H3N2v) cases in humans in 2016 and 2017. A cluste...
#1Beibei Chen (WHU: Wuhan University)H-Index: 2
#2Zhao Chen (WHU: Wuhan University)
Last. Xiangdong Chen (WHU: Wuhan University)H-Index: 8
view all 11 authors...
Recent environmental and metagenomic studies have considerably increased the repertoire of archaeal viruses and suggested that they play important roles in nutrient cycling in the biosphere. However, very little is known about how they regulate their life cycles and interact with their hosts. Here, we report that the life cycle of the temperate haloarchaeal virus SNJ1 is controlled by the product ORF4, a small protein belonging to the antitoxin MazE superfamily. We show that ORF4 controls the ly...
Top fields of study
Viral replication
Molecular biology