Outward subcortical curvature associated with sub-clinical depression symptoms in adolescents

Subclinical or subthreshold depressive symptoms (StD) are frequent in adolescence and are related to suicidality and onset of depression in adulthood, however, their neurobiology is poorly understood. We examined the relationship between StD and subcortical grey matter structures in unmedicated adolescents with no history of axis I diagnosis. 277 youths from Chicago aged 14 years participated, undergoing a structural MRI scan and completing the...