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NeuroImage: Clinical
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#1Seyed-Ahmad Ahmadi (LMU: Ludwig Maximilian University of Munich)H-Index: 14
#2Kai Bötzel (LMU: Ludwig Maximilian University of Munich)H-Index: 30
Last.Nassir Navab (TUM: Technische Universität München)H-Index: 61
view all 11 authors...
Abstract Background Transcranial B-mode sonography (TCS) can detect hyperechogenic speckles in the area of the substantia nigra (SN) in Parkinson's disease (PD). These speckles correlate with iron accumulation in the SN tissue, but an exact volumetric localization in and around the SN is still unknown. Areas of increased iron content in brain tissue can be detected in vivo with magnetic resonance imaging, using quantitative susceptibility mapping (QSM). Methods In this work, we i) acquire, co-re...
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#1Marie-Pierre Deiber (University of Geneva)H-Index: 17
#2Roland HaslerH-Index: 9
Last.Tomas Ros (University of Geneva)H-Index: 14
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Abstract Abnormal patterns of electrical oscillatory activity have been repeatedly described in adult ADHD. In particular, the alpha rhythm (8–12 Hz), known to be modulated during attention, has previously been considered as candidate biomarker for ADHD. In the present study, we asked adult ADHD patients to self-regulate their own alpha rhythm using neurofeedback (NFB), in order to examine the modulation of alpha oscillations on attentional performance and brain plasticity. Twenty-five adult ADH...
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#2Carlo CavaliereH-Index: 19
Last.Kupers Ron (UdeM: Université de Montréal)
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Abstract We investigated the effects of blindness on the structural and functional integrity of the corpus callosum and the anterior commissure (AC), which together form the two major components of the commissural pathways. Twelve congenitally blind (CB), 15 late blind (LB; mean onset of blindness of 16.6 ± 8.9 years), and 15 matched normally sighted controls (SC) participated in a multimodal brain imaging study. Magnetic resonance imaging(MRI) data were acquired using a 3T scanner, and included...
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#1Ana Alves Francisco (Albert Einstein College of Medicine)
#2John J. Foxe (UR: University of Rochester)H-Index: 76
Last.Sophie Molholm (UR: University of Rochester)H-Index: 38
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Abstract Cystinosis, a genetic rare disease characterized by cystine accumulation and crystallization, results in significant damage in a multitude of tissues and organs, such as the kidney, thyroid, eye, and brain. While Cystinosis’ impact on brain function is relatively mild compared to its effects on other organs, the increased lifespan of this population and thus potential for productive societal contributions have led to increased interest on the effects on brain function. Nevertheless, and...
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#1Daniela VecchioH-Index: 2
#2Fabrizio PirasH-Index: 24
Last.Gianfranco Spalletta (BCM: Baylor College of Medicine)H-Index: 52
view all 8 authors...
Abstract The effects of lithium treatment duration on deep grey matter structures in bipolar disorder are not well known. In this cross-sectional neuroimaging case-control study, we tested the hypothesis that shape characteristics of deep grey matter structures in bipolar disorder are associated with the duration of lithium treatment and with clinical phenomenology. In a setting of neuropsychiatry outpatient clinic, we included 74 patients with bipolar disorder (BD) and 74 matched healthy contro...
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#1Rong Ye (Harvard University)H-Index: 1
#2Alexandra Touroutoglou (Harvard University)H-Index: 13
Last.Stephen N. Gomperts (Harvard University)H-Index: 24
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Abstract Objective : Regional cortical thinning in dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD) may underlie some aspect of their clinical impairments; cortical atrophy likely reflects extensive Lewy body pathology with alpha-synuclein deposits, as well as associated Alzheimer's disease co-pathologies, when present. Here we investigated the topographic distribution of cortical thinning in these Lewy body diseases compared to cognitively normal PD and healthy non-PD contro...
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#2Roberta LanzilloH-Index: 20
Last.Mario Quarantelli (National Research Council)H-Index: 28
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Abstract Background regional analyses of markers of microstructural gray matter (GM) changes, including relaxation rates, have shown inconsistent correlations with physical and cognitive impairment in MS. Objective to assess voxelwise the correlation of the R1 and R2 relaxation rates with the physical and cognitive impairment in MS. Methods GM R1 and R2 relaxation rate maps were obtained in 241 relapsing-remitting MS patients by relaxometric segmentation of MRI studies. Correlations with the Exp...
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#1Lisanne M. Jenkins (NU: Northwestern University)H-Index: 11
#2Jessica J. Chiang (NU: Northwestern University)H-Index: 13
Last.Lei Wang (NU: Northwestern University)H-Index: 48
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Abstract Objective Subclinical or subthreshold depressive symptoms (StD) are frequent in adolescence and are related to suicidality and onset of depression in adulthood, however, their neurobiology is poorly understood. We examined the relationship between StD and subcortical grey matter structures in unmedicated adolescents with no history of axis I diagnosis Methods 277 youths from Chicago aged 14 years participated, undergoing a structural MRI scan and completing the Revised Children's Anxiet...
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#1Kento Nakagawa (UTokyo: University of Tokyo)H-Index: 5
#2Mitsuaki Takemi (UTokyo: University of Tokyo)H-Index: 5
Last.Kimitaka Nakazawa (UTokyo: University of Tokyo)H-Index: 31
view all 5 authors...
Abstract Despite their disabilities, top Paralympic athletes have better motor skills than able-bodied athletes. However, the neural underpinnings of these better motor skills remain unclear. We investigated the reorganization of the primary motor cortex (M1) in a Paralympic athlete with congenital amputation of both arms who holds the world record for the farthest accurate shot in archery (Amputee Archer: AA). We recorded brain activity during contraction of right toe, ankle, knee, and hip join...
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#1Batool Rizvi (Columbia University)H-Index: 3
#2Patrick J. Lao (Columbia University)H-Index: 7
Last.Adam M. Brickman (Columbia University)H-Index: 58
view all 10 authors...
Abstract White matter hyperintensities (WMH) are common radiological findings among older adults and strong predictors of age-related cognitive decline. Recent work has implicated WMH in the pathogenesis and symptom presentation of Alzheimer's disease (AD), which is characterized clinically primarily by a deficit in memory. The severity of WMH volume is typically quantified globally or by lobe, whereas white matter itself is organized by tracts and fiber classes. We derived WMH volumes within wh...
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Top fields of study
Magnetic resonance imaging
Psychology
Neuroscience
White matter
Medicine