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NeuroImage: Clinical
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#1Maxime Peralta (University of Rennes)
#2John S. H. Baxter (University of Rennes)H-Index: 1
Last. Pierre Jannin (University of Rennes)H-Index: 30
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Parkinson's Disease provokes alterations of subcortical deep gray matter, leading to subtle changes in the shape of several subcortical structures even before the manifestation of motor and non-motor clinical symptoms. We used an automated registration and segmentation pipeline to measure this structural alteration in one early and one advanced Parkinson's Disease (PD) cohorts, one prodromal stage cohort and one healthy control cohort. These structural alterations are then passed to a machine le...
#2John MuschelliH-Index: 17
Last. Rohit BakshiH-Index: 64
view all 11 authors...
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#1Elaine Foley (Aston University)H-Index: 3
#2Amanda G. Wood (Deakin University)H-Index: 29
Last. Stefano Seri (Aston University)H-Index: 29
view all 8 authors...
Abstract Recent theoretical models of language have emphasised the importance of integration within distributed networks during language processing. This is particularly relevant to young patients with epilepsy, as the topology of the functional network and its dynamics may be altered by the disease, resulting in reorganisation of functional language networks. Thus, understanding connectivity within the language network in patients with epilepsy could provide valuable insights into healthy and p...
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#1Yuwen Hung (MIT: Massachusetts Institute of Technology)
#2Mai Uchida (Harvard University)H-Index: 13
Last. Anastasia Yendiki (Harvard University)H-Index: 21
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Abstract Emotional dysregulation symptoms in youth frequently predispose individuals to increased risk for mood disorders and other mental health difficulties. These symptoms are also known as a behavioral risk marker in predicting pediatric mood disorders. The underlying neural mechanism of emotional dysregulation, however, remains unclear. This study used the diffusion tensor imaging (DTI) technique to identify anatomically specific variation in white-matter microstructure that is associated w...
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#1Britta Hahn (UMB: University of Maryland, Baltimore)H-Index: 21
#2Gi-Yeul Bae (ASU: Arizona State University)H-Index: 10
Last. James M. Gold (UMB: University of Maryland, Baltimore)H-Index: 84
view all 6 authors...
Abstract A frequent finding when studying substrates of working memory (WM) deficits in people with schizophrenia (PSZ) is task-induced hyperactivation relative to healthy control subjects (HCS) when WM load is low. Hyperactivation accompanying similar performance is commonly attributed to cognitive deficits rendering relatively easy operations more resource-consuming. To test if hyperactivation at low load really is secondary to cognitive impairment in PSZ, we re-analyzed functional MRI data sh...
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#1Stephan Furger (University of Bern)
#2Antje Stahnke (University of Bern)
Last. Werner Strik (University of Bern)H-Index: 48
view all 9 authors...
Abstract The perception of faces and consequent social inferences are fundamental for interpersonal communication. While facial expression is important for interindividual communication, constitutional and acquired features are crucial for basic emotions of attraction or repulsion. An emotional bias in face processing has been shown in schizophrenia, but the neurobiological mechanisms are unclear. Studies on the interaction between face processing and the emotional state of healthy individuals m...
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#1Dorian VogelH-Index: 1
#2Ashesh ShahH-Index: 2
Last. Simone HemmH-Index: 16
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Abstract Deep brain stimulation (DBS) therapy requires extensive patient-specific planning prior to implantation to achieve optimal clinical outcomes. Collective analysis of patient’s brain images is promising in order to provide more systematic planning assistance. In this paper the design of a normalization pipeline using a group specific multi-modality iterative template creation process. The focus was to compare the performance of a selection of freely available registration tools and select...
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#1Le Gjerum (UCPH: University of Copenhagen)H-Index: 2
#2Kristian Steen Frederiksen (UCPH: University of Copenhagen)H-Index: 12
Last. Juha KoikkalainenH-Index: 22
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Abstract 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography (2-[18F]FDG-PET) has an emerging supportive role in dementia diagnostic as distinctive metabolic patterns are specific for Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). Previous studies have demonstrated that a data-driven decision model based on the disease state index (DSI) classifier supports clinicians in the differential diagnosis of dementia by using different combinations o...
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#1Gerhard S. Drenthen (UM: Maastricht University)H-Index: 1
#2Floor Fasen (UM: Maastricht University)
Last. Jacobus F.A. Jansen (UM: Maastricht University)H-Index: 33
view all 10 authors...
Abstract While cognitive impairments are not generally considered to be part of the childhood absence epilepsy (CAE) syndrome, some recent studies report cognitive, mainly attentional, deficits. Here we set out to investigate the whole brain functional network of children with CAE and controls. Furthermore, the possible relation of the functional network abnormalities with epilepsy and neurocognitive characteristics is studied. Seventeen children with childhood absence epilepsy (aged 9.2 ± 2.1 y...
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#1Isabelle C. Ridderbusch (University of Marburg)
#2Yunbo Yang (University of Marburg)H-Index: 3
Last. U. Lueken (Humboldt University of Berlin)H-Index: 2
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Abstract Neuronal nitric oxide synthase (NOS-I) impacts on fear/anxiety-like behavior in animals. In humans, the short (S) allele of a functional promotor polymorphism of NOS1 (NOS1 ex1f-VNTR) has been shown to be associated with higher anxiety and altered fear conditioning in healthy subjects in the amygdala and hippocampus (AMY/HIPP). Here, we explore the role of NOS1 ex1f-VNTR as a pathophysiological correlate of panic disorder and agoraphobia (PD/AG). In a sub-sample of a multicenter cogniti...
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Top fields of study
Magnetic resonance imaging
Psychology
Neuroscience
White matter
Medicine