Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors
Abstract
Cysteinyl leukotriene G protein-coupled receptors CysLT1 and CysLT2 regulate pro-inflammatory responses associated with allergic disorders. While selective inhibition of CysLT1R has been used for treating asthma and associated diseases for over two decades, CysLT2R has recently started to emerge as a potential drug target against atopic asthma, brain injury and central nervous system disorders, as well as several types of cancer. Here, we...
Paper Details
Title
Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors
Published Date
Dec 6, 2019
Journal
Volume
10
Issue
1
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