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Aleksandra Luginina
Moscow Institute of Physics and Technology
Crystal structureG protein-coupled receptorCysteinyl leukotriene receptor 2StereochemistryBiology
13Publications
2H-index
14Citations
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Publications 13
Newest
#1Anastasiia Gusach (MIPT: Moscow Institute of Physics and Technology)H-Index: 2
#2Ivan Maslov (MIPT: Moscow Institute of Physics and Technology)H-Index: 1
Last. Vadim Cherezov (SC: University of Southern California)H-Index: 63
view all 6 authors...
G protein-coupled receptors (GPCRs) constitute the largest superfamily of membrane proteins that are involved in regulation of sensory and physiological processes and implicated in many diseases. The last decade revolutionized the GPCR field by unraveling multiple high-resolution structures of many different receptors in complexes with various ligands and signaling partners. A complete understanding of the complex nature of GPCR function is, however, impossible to attain without combining static...
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#1Tatsiana Varaksa (NASB: National Academy of Sciences of Belarus)
#2Sergey Bukhdruker (MIPT: Moscow Institute of Physics and Technology)
Last. Dmitry Zabelskiy (MIPT: Moscow Institute of Physics and Technology)
view all 34 authors...
Mycobacterium tuberculosis (Mtb) infection is among top ten causes of death worldwide, and the number of drug-resistant strains is increasing. The direct interception of human immune signaling molecules by Mtb remains elusive, limiting drug discovery. Oxysterols and secosteroids regulate both innate and adaptive immune responses. Here we report a functional, structural, and bioinformatics study of Mtb enzymes initiating cholesterol catabolism and demonstrated their interrelation with human immun...
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#1Anastasiia GusachH-Index: 2
Last. Vadim CherezovH-Index: 63
view all 23 authors...
Source
#1Anastasiia GusachH-Index: 2
Last. Vadim CherezovH-Index: 63
view all 23 authors...
Source
#1Anastasiia Gusach (MIPT: Moscow Institute of Physics and Technology)H-Index: 2
#2Aleksandra Luginina (MIPT: Moscow Institute of Physics and Technology)H-Index: 2
Last. Vadim CherezovH-Index: 63
view all 24 authors...
Cysteinyl leukotriene G protein-coupled receptors CysLT1 and CysLT2 regulate pro-inflammatory responses associated with allergic disorders. While selective inhibition of CysLT1R has been used for treating asthma and associated diseases for over two decades, CysLT2R has recently started to emerge as a potential drug target against atopic asthma, brain injury and central nervous system disorders, as well as several types of cancer. Here, we describe four crystal structures of CysLT2R in complex wi...
2 CitationsSource
#2Anastasiia GusachH-Index: 2
Last. Vadim CherezovH-Index: 63
view all 24 authors...
Source
#2Anastasiia GusachH-Index: 2
Last. Vadim CherezovH-Index: 63
view all 24 authors...
Source
#1Aleksandra Luginina (MIPT: Moscow Institute of Physics and Technology)H-Index: 2
#2Anastasiia Gusach (MIPT: Moscow Institute of Physics and Technology)H-Index: 2
Last. Vadim Cherezov (SC: University of Southern California)H-Index: 63
view all 26 authors...
The G protein–coupled cysteinyl leukotriene receptor CysLT1R mediates inflammatory processes and plays a major role in numerous disorders, including asthma, allergic rhinitis, cardiovascular disease, and cancer. Selective CysLT1R antagonists are widely prescribed as antiasthmatic drugs; however, these drugs demonstrate low effectiveness in some patients and exhibit a variety of side effects. To gain deeper understanding into the functional mechanisms of CysLTRs, we determined the crystal structu...
7 CitationsSource
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