Von Willebrand factor and ADAMTS13 impact on the outcome of Staphylococcus aureus sepsis

Previous clinical evidence correlates levels of von Willebrand factor (VWF) and its cleaving protease ADAMTS13 with outcome in septic patients. No previous studies addressed if VWF and ADAMTS13 affected the outcome of Staphylococcus aureus sepsis.We studied the role of VWF and ADAMTS13 in S. aureus sepsis both in patients and in mice.VWF levels and ADAMTS13 activity levels were measured in plasma samples from 89 S. aureus bacteremia patients by...