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Severien Meyers
Katholieke Universiteit Leuven
Internal medicineCardiologyEndocarditisVon Willebrand factorStaphylococcus aureusDiabetes mellitusMedicineMicrobiology
6Publications
1H-index
13Citations
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Publications 6
Newest
#1Angelika Jochim (University of Tübingen)H-Index: 2
#2Lea Adolf (University of Tübingen)
Last. Dirk Jan Slotboom (UG: University of Groningen)H-Index: 42
view all 11 authors...
Energy-coupling factor type (ECF-transporters) represent trace nutrient acquisition systems. Substrate binding components of ECF-transporters are membrane proteins with extraordinary affinity, allowing them to scavenge trace amounts of ligand. A number of molecules have been described as substrates of ECF-transporters, but an involvement in iron-acquisition is unknown. Host-induced iron limitation during infection represents an effective mechanism to limit bacterial proliferation. We identified ...
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#1Angelika Jochim (University of Tübingen)H-Index: 2
#2Lea Adolf (University of Tübingen)
Last. Dirk Jan Slotboom (UG: University of Groningen)H-Index: 42
view all 11 authors...
Source
#1Marijke Peetermans (Katholieke Universiteit Leuven)H-Index: 13
#2Severien Meyers (Katholieke Universiteit Leuven)H-Index: 1
Last. Peter Verhamme (Katholieke Universiteit Leuven)H-Index: 43
view all 12 authors...
BACKGROUND: Previous clinical evidence correlates levels of von Willebrand factor (VWF) and its cleaving protease ADAMTS13 with outcome in septic patients. No previous studies addressed if VWF and ADAMTS13 affected the outcome of Staphylococcus aureus sepsis. OBJECTIVES: We studied the role of VWF and ADAMTS13 in S. aureus sepsis both in patients and in mice. METHODS: VWF levels and ADAMTS13 activity levels were measured in plasma samples from 89 S. aureus bacteremia patients by chemiluminescent...
1 CitationsSource
#1Laurens Liesenborghs (Katholieke Universiteit Leuven)H-Index: 11
#2Severien Meyers (Katholieke Universiteit Leuven)H-Index: 1
Last. Peter Verhamme (Katholieke Universiteit Leuven)H-Index: 43
view all 4 authors...
Infective endocarditis is a life-threatening and enigmatic disease with a mortality of 30% and a pathophysiology that is poorly understood. However, at its core, an endocarditis lesion is mainly a fibrin and platelet blood clot infested with bacteria, clinging at the cardiac valves. Infective endocarditis therefore serves as a paradigm of immunothrombosis gone wrong. Immunothrombosis refers to the entanglement of the coagulation system with innate immunity and the role of coagulation in the isol...
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#1Laurens Liesenborghs (Katholieke Universiteit Leuven)H-Index: 11
#2Severien Meyers (Katholieke Universiteit Leuven)H-Index: 1
Last. Peter Verhamme (Katholieke Universiteit Leuven)H-Index: 43
view all 16 authors...
AIMS: The pathogenesis of endocarditis is not well understood resulting in unsuccessful attempts at prevention. Clinical observations suggest that Staphylococcus aureus infects either damaged or inflamed heart valves. Using a newly developed endocarditis mouse model, we therefore studied the initial adhesion of S. aureus in both risk states. METHODS AND RESULTS: Using 3D confocal microscopy, we examined the adhesion of fluorescent S. aureus to murine aortic valves. To mimic different risk states...
6 CitationsSource
#1Severien Meyers (Katholieke Universiteit Leuven)H-Index: 1
#2Laurens Liesenborghs (Katholieke Universiteit Leuven)H-Index: 11
Last. Kimberly Martinod (Katholieke Universiteit Leuven)H-Index: 22
view all 7 authors...
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