P4-167: PROGENITOR CELL SENESCENCE IS LINKED TO NEUROVASCULAR DYSFUNCTION AND LOSS OF BRAIN NETWORK CONNECTIVITY

Daniel A. Nation; Duke Han; Jung Jang; Shubir Dutt; Jean K. Ho; Belinda Yew; Alick Tan; Elissa C. McIntosh; Anna E. Blanken; Aimee Gaubert

doi:https://doi.org/10.1016/j.jalz.2019.06.3829

doi.org/10.1016/j.jalz.2019.06.3829

P4-167: PROGENITOR CELL SENESCENCE IS LINKED TO NEUROVASCULAR DYSFUNCTION AND LOSS OF BRAIN NETWORK CONNECTIVITY

,

..., Aimee Gaubert

Alzheimer's & Dementia

Volume: 15, Issue: 7S_Part_26

Published: Jul 1, 2019

Abstract

Depletion of circulating progenitor cell levels has been observed in cognitive impairment and dementia due to Alzheimer's disease and vascular disease. We recently reported depletion of circulating progenitor cells in association with perfusion abnormalities, smaller regional brain volume and worse cognitive performance. No studies to date have investigated whether progenitor cell senescence, indicated by beta-galactosidase (beta-gal) staining,...

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Paper Details

Title

P4-167: PROGENITOR CELL SENESCENCE IS LINKED TO NEUROVASCULAR DYSFUNCTION AND LOSS OF BRAIN NETWORK CONNECTIVITY

DOI

doi.org/10.1016/j.jalz.2019.06.3829

Published Date

Jul 1, 2019

Journal

Alzheimer's & Dementia

Volume

15

Issue

7S_Part_26

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