High-intensity interval training prevents cognitive-motor impairment and serum BDNF level reduction in parkinson mice model

Parkinson’s disease (PD) is a neurodegenerative disease characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra pars compact (SNpc). Previous studies have shown that cognitive deficits and motor impairment symptoms seen in PD and that physical exercise may exert beneficial effects on PD. In most cases, brain-derived neurotrophic factor (BDNF) is involved in such effects. However, little is known on the role of...