Sex‐dependency of oestrogen‐induced structural synaptic plasticity: Inhibition of aromatase versus application of estradiol in rodents

Sex‐dependent differences in learning and memory formation in humans have been frequently shown. The mechanisms underlying the formation and retention of memories are assumed to involve synaptic plasticity in the hippocampus. Estradiol was shown to effect synaptic plasticity in the hippocampus of rodents. The effects after exogenous application of estradiol to animals frequently produce inconsistent results, in particular, if sex is not...