Gabriele M. Rune
University of Hamburg
EndocrinologyHippocampal formationAromataseHippocampusBiology
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Publications 94
#1Iris Haumann (UHH: University of Hamburg)H-Index: 2
#2Muriel Anne Sturm (UHH: University of Hamburg)
Last. Gabriele M. Rune (UHH: University of Hamburg)H-Index: 30
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Summary In the rodent ventricular-subventricular zone (V-SVZ) neurons are generated throughout life. They migrate along the rostral migratory stream (RMS) into the olfactory bulb prior to their final differentiation into interneurons and integration into local circuits. Estrogen receptors (ERs) are steroid hormone receptors with important functions in neurogenesis and synaptic plasticity. In this study, we show that the estrogen receptor GPER1 is expressed in subsets of cells within the V-SVZ of...
#1Nicola Brandt (UHH: University of Hamburg)H-Index: 8
#2Ricardo Vierk (UHH: University of Hamburg)H-Index: 6
Last. Gabriele M. Rune (UHH: University of Hamburg)H-Index: 30
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Numerous studies provide increasing evidence, which supports the ideas that every cell in the brain of males may differ from those in females due to differences in sex chromosome complement as well as in response to hormonal effects. In this study, we address the question as to whether actions of neurosteroids, thus steroids, which are synthesized and function within the brain, contribute to sex-specific hippocampal synaptic plasticity. We have previously shown that predominantly in the female h...
2 CitationsSource
#1Jasmine Pahle (UHH: University of Hamburg)H-Index: 1
#2Mary Muhia (UHH: University of Hamburg)H-Index: 3
Last. Bianka Brunne (UHH: University of Hamburg)H-Index: 7
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Reelin is an extracellular matrix protein, known for its dual role in neuronal migration during brain development and in synaptic plasticity at adult stages. During the perinatal phase, Reelin expression switches from Cajal-Retzius (CR) cells, its main source before birth, to inhibitory interneurons (IN), the main source of Reelin in the adult forebrain. IN-derived Reelin has been associated with schizophrenia and temporal lobe epilepsy; however, the functional role of Reelin from INs is present...
#1Nicola Brandt (UHH: University of Hamburg)H-Index: 8
#2Gabriele M. Rune (UHH: University of Hamburg)H-Index: 30
1 CitationsSource
#1Nicola BrandtH-Index: 8
#2Gabriele M. RuneH-Index: 30
#1Christina Gölz (University of Mainz)H-Index: 2
#2Florian Paul Kirchhoff (University of Mainz)H-Index: 1
Last. Michael K. E. Schäfer (University of Mainz)H-Index: 21
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1 CitationsSource
#1Max Anstötz (UHH: University of Hamburg)H-Index: 1
#2Meliha Karsak (UHH: University of Hamburg)H-Index: 13
Last. Gabriele M. Rune (UHH: University of Hamburg)H-Index: 30
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Background About 3%–5% of adults with membranous nephropathy have autoantibodies directed against thrombospondin type 1 domain–containing 7A (THSD7A), a podocyte-expressed transmembrane protein. However, the temporal and spatial expression of THSD7A and its biologic function for podocytes are unknown, information that is needed to understand the effects of THSD7A autoantibodies in this disease. Methods Using a variety of microscopic techniques, we analyzed THSD7A localization in postnatal, adult...
3 CitationsSource
#1Tobias Sommer (UHH: University of Hamburg)H-Index: 26
#2Katharina Richter (UHH: University of Hamburg)H-Index: 1
Last. Janine Bayer (UHH: University of Hamburg)H-Index: 7
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17-Beta-estradiol (E2) stimulates neural plasticity and dopaminergic transmission in the prefrontal cortex, which is critically involved in attentional control, working memory, and other executive functions. Studies investigating E2’s actions on prefrontally mediated behavior in the course of the menstrual cycle or during hormone replacement therapy are inconclusive, with numerous null findings as well as beneficial and detrimental effects. The current study focused on the effect of E2 on attent...
2 CitationsSource
#1Maurice Meseke (UHH: University of Hamburg)H-Index: 4
#2Florian Neumüller (UHH: University of Hamburg)
Last. Roland A. Bender (UHH: University of Hamburg)H-Index: 29
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Abstract HCN1 compartmentalization in CA1 pyramidal cells, essential for hippocampal information processing, is believed to be controlled by the extracellular matrix protein Reelin. Expression of Reelin, in turn, is stimulated by 17β-estradiol (E2). In this study, we therefore tested whether E2 regulates the compartmentalization of HCN1 in CA1 via Reelin. In organotypic entorhino-hippocampal cultures, we found that E2 promotes HCN1 distal dendritic enrichment via the G protein–coupled estrogen r...