CRISPR-Pass: Gene Rescue of Nonsense Mutations Using Adenine Base Editors
Abstract
A nonsense mutation is a substitutive mutation in a DNA sequence that causes a premature termination during translation and produces stalled proteins, resulting in dysfunction of a gene. Although it usually induces severe genetic disorders, there are no definite methods for inducing read through of premature termination codons (PTCs). Here, we present a targeted tool for bypassing PTCs, named CRISPR-pass, that uses CRISPR-mediated adenine base...
Paper Details
Title
CRISPR-Pass: Gene Rescue of Nonsense Mutations Using Adenine Base Editors
Published Date
Aug 1, 2019
Journal
Volume
27
Issue
8
Pages
1364 - 1371
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