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Dong Hyun Jo
Seoul National University Hospital
69Publications
13H-index
523Citations
Publications 70
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#1Dong Hyun Jo (Seoul National University Hospital)H-Index: 13
#2Dong Woo SongH-Index: 1
Last.Jungmin Lee (Handong Global University)H-Index: 4
view all 13 authors...
Leber congenital amaurosis (LCA), one of the leading causes of childhood-onset blindness, is caused by autosomal recessive mutations in several genes including RPE65. In this study, we performed CRISPR-Cas9–mediated therapeutic correction of a disease-associated nonsense mutation in Rpe65 in rd12 mice, a model of human LCA. Subretinal injection of adeno-associated virus carrying CRISPR-Cas9 and donor DNA resulted in >1% homology-directed repair and ~1.6% deletion of the pathogenic stop codon in ...
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#1Wonjin Park (Kangwon National University)H-Index: 5
#2Yi-Yong Baek (Kangwon National University)H-Index: 2
Last.Young-Myeong Kim (Kangwon National University)H-Index: 64
view all 15 authors...
1 CitationsSource
#1Choongil Lee (SNU: Seoul National University)H-Index: 5
#2Dong Hyun Jo (Seoul National University Hospital)H-Index: 13
Last.Sangsu Bae (Hanyang University)H-Index: 15
view all 9 authors...
A nonsense mutation is a substitutive mutation in a DNA sequence that causes a premature termination during translation and produces stalled proteins, resulting in dysfunction of a gene. Although it usually induces severe genetic disorders, there are no definite methods for inducing read through of premature termination codons (PTCs). Here, we present a targeted tool for bypassing PTCs, named CRISPR-pass, that uses CRISPR-mediated adenine base editors. CRISPR-pass, which should be applicable to ...
2 CitationsSource
#1Dong Hyun Jo (SNU: Seoul National University)H-Index: 13
#2Jin Hyoung Kim (SNU: Seoul National University)H-Index: 27
Last.KimJi-Young (SNU: Seoul National University)H-Index: 141
view all 3 authors...
Uveal melanoma is the most common intraocular primary malignant tumor in adults, and retinoblastoma is the one in children. Current mainstay treatment options include chemotherapy using conventional drugs and enucleation, the total removal of the eyeball. Targeted therapies based on profound understanding of molecular mechanisms of ocular tumors may increase the possibility of preserving the eyeball and the vision. Tyrosine kinases, which modulate signaling pathways regarding various cellular fu...
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#1Joo Young Lee (Seoul National University Hospital)H-Index: 5
#2Dong Hyun Jo (SNU: Seoul National University)H-Index: 13
Last.Sun Ha PaekH-Index: 39
view all 14 authors...
Currently, the two primary patient-derived xenograft (PDX) models of glioblastoma are established through intracranial or subcutaneous injection. In this study, a novel PDX model of glioblastoma was developed via intravitreal injection to facilitate tumor formation in a brain-mimicking microenvironment with improved visibility and fast development. Glioblastoma cells were prepared from the primary and recurrent tumor tissues of a 39-year-old female patient. To demonstrate the feasibility of intr...
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#1Dong Hyun Jo (Seoul National University Hospital)H-Index: 13
#2Jang Hyuk Yun (SNU: Seoul National University)H-Index: 5
Last.Chung-Hyun Cho (SNU: Seoul National University)H-Index: 24
view all 6 authors...
2 CitationsSource
#1Dong Hyun Jo (Seoul National University Hospital)H-Index: 13
#2Taeyoung Koo (Kyung Hee University)H-Index: 15
Last.KimJi-Young (SNU: Seoul National University)H-Index: 141
view all 6 authors...
Genome editing with CRISPR systems provides an unprecedented opportunity to modulate cellular responses in pathological conditions by inactivating undruggable targets, such as transcription factors. Previously, we demonstrated that the smallest Cas9 ortholog characterized to date, from Campylobacter jejuni (CjCas9) targeted to Hif1a and delivered in an adeno-associated virus (AAV) vector, effectively suppressed pathological choroidal neovascularization in the mouse retina. Before implementation ...
3 CitationsSource
#1Aeri Yoon (Gwangju Institute of Science and Technology)
#2Sora Im (Gwangju Institute of Science and Technology)H-Index: 1
Last.Woo Jin Park (Gwangju Institute of Science and Technology)H-Index: 26
view all 8 authors...
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#1Seung Hyun Park (Yonsei University)H-Index: 5
#2Dong Hyun Jo (SNU: Seoul National University)H-Index: 13
Last.WonHyoung Ryu (Yonsei University)H-Index: 15
view all 9 authors...
Abstract To treat retinal diseases, intravitreal injection is commonly performed to deliver therapeutic agents to the eye. However, intravitreal injection poses potential risks of ocular complications such as endophthalmitis, retinal detachment, and ocular hemorrhage. Thus, it is desired to develop a minimally invasive and therapeutically effective ocular drug delivery system without full penetration into the sclera. Here, we studied the possibility of precisely-controlled insertion of microneed...
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