Late aging–associated increases in L-DOPA–induced dyskinesia are accompanied by heightened neuroinflammation in the hemi-parkinsonian rat

Aging is a primary risk factor for the development of Parkinson's disease (PD), and aging differentially predicts the incidence of L-DOPA–induced dyskinesia (LID). The goal of this work was to establish whether late aging–associated exacerbation of LID would be related to neuroinflammation in the hemi-parkinsonian rat. Two studies were conducted in which adult (3 months) and aged (18 months) male Fischer 344 rats bearing unilateral...