A CRISPR monkey model unravels a unique function of PINK1 in primate brains
Abstract
Genetically modified rodent models have been valuable for investigating the pathogenesis of neurodegenerative diseases such as Parkinson’s disease (PD). Based on the fact that mutations in the PINK1 gene cause autosomal recessive juvenile parkinsonism, a number of mouse models with deletion of the PINK1 gene were generated. However, these PINK1 knockout mouse models fail to recapitulate the selective and overt neurodegeneration seen in PD...
Paper Details
Title
A CRISPR monkey model unravels a unique function of PINK1 in primate brains
Published Date
May 2, 2019
Journal
Volume
14
Issue
1
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