Xiao-Jiang Li
Emory University
174Publications
61H-index
14.4kCitations
Publications 174
Newest
Published on Jan 7, 2019in The Neuroscientist 7.46
Shanshan Huang (Huazhong University of Science and Technology), Suiqiang Zhu (Huazhong University of Science and Technology)+ 1 AuthorsLi Shihua76
Estimated H-index: 76
(Emory University)
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Published on Feb 15, 2019in Cell Research 15.39
Weili Yang9
Estimated H-index: 9
,
Yunbo Liu + 12 AuthorsZhengyi Yang
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Published on Feb 15, 2019in Human Molecular Genetics 4.90
Zhuchi Tu7
Estimated H-index: 7
(Jinan University),
Hui Zhao2
Estimated H-index: 2
(Chinese Academy of Sciences)
+ 14 AuthorsYingqi Lin (Jinan University)
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Published on Nov 29, 2018in Frontiers in Physiology 3.39
Su Yang8
Estimated H-index: 8
(Emory University),
Shihua Li (Jinan University), Xiao-Jiang Li61
Estimated H-index: 61
(Emory University)
All human behaviors, including the control of energy homeostasis, are ultimately mediated by neuronal activities in the brain. Neurotrophic factors represent a protein family that plays important roles in regulating neuronal development, function, and survival. It has been well established that canonical neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF), play important roles in the central regulation of energy homeostasis. Recently, a c...
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Published on May 1, 2018in Cell 31.40
Sen Yan10
Estimated H-index: 10
(Jinan University),
Zhuchi Tu7
Estimated H-index: 7
(Jinan University)
+ 18 AuthorsChengdan Lai4
Estimated H-index: 4
(Guangzhou Institutes of Biomedicine and Health)
Summary Huntington's disease (HD) is characterized by preferential loss of the medium spiny neurons in the striatum. Using CRISPR/Cas9 and somatic nuclear transfer technology, we established a knockin (KI) pig model of HD that endogenously expresses full-length mutant huntingtin (HTT). By breeding this HD pig model, we have successfully obtained F1 and F2 generation KI pigs. Characterization of founder and F1 KI pigs shows consistent movement, behavioral abnormalities, and early death, which are...
18 Citations Source Cite
Published on Mar 1, 2018in Molecular Neurobiology 5.08
Yoon Lim13
Estimated H-index: 13
(Flinders University),
Linda L. Wu13
Estimated H-index: 13
(Flinders University)
+ 7 AuthorsXin-Fu Zhou42
Estimated H-index: 42
(University of South Australia)
When BDNF binds to its receptors, TrkB and p75NTR, the BDNF-receptor complex is endocytosed and trafficked to the cell body for downstream signal transduction, which plays a critical role in neuronal functions. Huntingtin-associated protein 1 (HAP1) is involved in trafficking of vesicles intracellularly and also interacts with several membrane proteins including TrkB. Although it has been known that HAP1 has functions in vesicular trafficking and receptor stabilisation, it is not yet established...
3 Citations Source Cite
Published on Dec 1, 2018in Molecular Neurodegeneration 6.43
Jifeng Guo3
Estimated H-index: 3
(Central South University),
Yiting Cui3
Estimated H-index: 3
(Central South University)
+ 8 AuthorsSu Yang8
Estimated H-index: 8
(Emory University)
Background Spinocerebellar ataxia 17 (SCA17) belongs to the family of neurodegenerative diseases caused by polyglutamine (polyQ) expansion. In SCA17, polyQ expansion occurs in the TATA box binding protein (TBP) and leads to the misfolding of TBP and the preferential degeneration in the cerebellar Purkinje neurons. Currently there is no effective treatment for SCA17. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a recently identified neurotrophic factor, and increasing MANF expres...
3 Citations Source Cite
Sen Yan10
Estimated H-index: 10
(Jinan University),
Zhuchi Tu7
Estimated H-index: 7
(Jinan University)
+ 1 AuthorsXiao-Jiang Li61
Estimated H-index: 61
(Emory University)
Abstract Aging-related brain diseases consist of a number of important neurodegenerative disorders, including Alzheimer's, Parkinson's, and Huntington's diseases, all of which have become more prevalent as the life expectancy of humans is prolonged. Age-dependent brain disorders are associated with both environmental insults and genetic mutations. For those brain disorders that are inherited, gene editing is an important tool for establishing animal models to investigate the pathogenesis of dise...
3 Citations Source Cite
Published on Dec 1, 2018in Cell Reports 8.03
Su Yang8
Estimated H-index: 8
(Emory University),
Li Shihua76
Estimated H-index: 76
(Emory University),
Xiao-Jiang Li61
Estimated H-index: 61
(Emory University)
Summary Virus-mediated expression of CRISPR/Cas9 is commonly used for genome editing in animal brains to model or treat neurological diseases, but the potential neurotoxicity of overexpressing bacterial Cas9 in the mammalian brain remains unknown. Through RNA sequencing (RNA-seq) analysis, we find that virus-mediated expression of Cas9 influences the expression of genes involved in neuronal functions. Reducing the half-life of Cas9 by tagging with geminin, whose expression is regulated by the ce...
1 Citations Source Cite
Published on Dec 1, 2017in Scientific Reports 4.12
Zhuchi Tu7
Estimated H-index: 7
,
Weili Yang9
Estimated H-index: 9
+ 10 AuthorsSu Yang8
Estimated H-index: 8
18 Citations Source Cite
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