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Xiao-Jiang Li
Emory University
176Publications
61H-index
14.5kCitations
Publications 176
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#1Hui Zhao (CAS: Chinese Academy of Sciences)H-Index: 2
#2Qiqi Wang (CAS: Chinese Academy of Sciences)
Last.Xiao-Jiang Li (Emory University)H-Index: 61
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Despite the substantial progress made in identifying genetic defects in autism spectrum disorder (ASD), the etiology for majority of ASD individuals remains elusive. Maternal exposure to valproic acid (VPA), a commonly prescribed antiepileptic drug during pregnancy in human, has long been considered a risk factor to contribute to ASD susceptibility in offspring from epidemiological studies in humans. The similar exposures in murine models have provided tentative evidence to support the finding f...
#1Weili Yang (Emory University)
#2Li Shihua (Emory University)H-Index: 76
Last.Xiao-Jiang Li (Emory University)H-Index: 61
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Genetically modified rodent models have been valuable for investigating the pathogenesis of neurodegenerative diseases such as Parkinson’s disease (PD). Based on the fact that mutations in the PINK1 gene cause autosomal recessive juvenile parkinsonism, a number of mouse models with deletion of the PINK1 gene were generated. However, these PINK1 knockout mouse models fail to recapitulate the selective and overt neurodegeneration seen in PD patient brains. Recently, we generated a non-human primat...
#1Shanshan Huang (HUST: Huazhong University of Science and Technology)
#2Suiqiang Zhu (HUST: Huazhong University of Science and Technology)
Last.Li Shihua (Emory University)H-Index: 76
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Polyglutamine (polyQ) diseases are a group of hereditary neurodegenerative disorders caused by expansion of unstable polyQ repeats in their associated disease proteins. To date, the pathogenesis of each disease remains poorly understood, and there are no effective treatments. Growing evidence has indicated that, in addition to neurodegeneration, polyQ-expanded proteins can cause a wide array of abnormalities in peripheral tissues. Indeed, polyQ-expanded proteins are ubiquitously expressed throug...
#1Sen Yan (JNU: Jinan University)H-Index: 11
#2Li Shihua (Emory University)H-Index: 76
Last.Xiao-Jiang Li (Emory University)H-Index: 61
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Abstract Animal models that can mimic human diseases are the important tools for investigating the pathogenesis of the diseases and finding a way for treatment. There is no doubt that small animal models have provided a wealth of information regarding disease pathogenesis and also offered widely used tools to develop therapeutic strategies. Rodent models have been very valuable for investigators to understand the mechanisms underlying misfolded protein-mediated neuronal dysfunction and behaviora...
A hallmark of Alzheimer’s disease (AD) pathogenesis is the accumulation of extracellular plaques mainly composed of amyloid-β (Aβ) derived from amyloid precursor protein (APP) cleavage. Recent reports suggest that transport of APP in vesicles with huntingtin-associated protein-1 (HAP1) negatively regulates Aβ production. In neurons, HAP1 forms a stable complex with Abelson helper integration site-1 (AHI1), in which mutations cause neurodevelopmental and psychiatric disorders. HAP1 and AHI1 inter...
#1Weili Yang (JNU: Jinan University)H-Index: 9
#2Yunbo Liu (Peking Union Medical College)H-Index: 1
Last.Zhengyi Yang (CAS: Chinese Academy of Sciences)H-Index: 14
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#1Zhuchi Tu (JNU: Jinan University)H-Index: 7
#2Hui Zhao (CAS: Chinese Academy of Sciences)H-Index: 2
Last.Yingqi Lin (JNU: Jinan University)
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#1Su Yang (Emory University)H-Index: 9
#2Li Shihua (Emory University)H-Index: 76
Last.Xiao-Jiang Li (Emory University)H-Index: 61
view all 3 authors...
Summary Virus-mediated expression of CRISPR/Cas9 is commonly used for genome editing in animal brains to model or treat neurological diseases, but the potential neurotoxicity of overexpressing bacterial Cas9 in the mammalian brain remains unknown. Through RNA sequencing (RNA-seq) analysis, we find that virus-mediated expression of Cas9 influences the expression of genes involved in neuronal functions. Reducing the half-life of Cas9 by tagging with geminin, whose expression is regulated by the ce...
#1Jifeng Guo (CSU: Central South University)H-Index: 4
#2Yiting Cui (CSU: Central South University)H-Index: 3
Last.Su Yang (Emory University)H-Index: 9
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Background Spinocerebellar ataxia 17 (SCA17) belongs to the family of neurodegenerative diseases caused by polyglutamine (polyQ) expansion. In SCA17, polyQ expansion occurs in the TATA box binding protein (TBP) and leads to the misfolding of TBP and the preferential degeneration in the cerebellar Purkinje neurons. Currently there is no effective treatment for SCA17. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a recently identified neurotrophic factor, and increasing MANF expres...
#1Su Yang (Emory University)H-Index: 9
#2Li Shihua (JNU: Jinan University)H-Index: 76
Last.Xiao-Jiang Li (Emory University)H-Index: 61
view all 3 authors...
All human behaviors, including the control of energy homeostasis, are ultimately mediated by neuronal activities in the brain. Neurotrophic factors represent a protein family that plays important roles in regulating neuronal development, function, and survival. It has been well established that canonical neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF), play important roles in the central regulation of energy homeostasis. Recently, a c...
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