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Xiao-Jiang Li
Emory University
176Publications
61H-index
14.5kCitations
Publications 176
Newest
Published on Apr 1, 2019in Cell Research 15.39
Weili Yang9
Estimated H-index: 9
(Jinan University),
Yunbo Liu1
Estimated H-index: 1
(Peking Union Medical College)
+ 12 AuthorsZhengyi Yang3
Estimated H-index: 3
(Chinese Academy of Sciences)
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Published on Feb 15, 2019in Human Molecular Genetics 4.90
Zhuchi Tu7
Estimated H-index: 7
(Jinan University),
Hui Zhao2
Estimated H-index: 2
(Chinese Academy of Sciences)
+ 14 AuthorsYingqi Lin (Jinan University)
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Published on Feb 1, 2019in Cell Regeneration
Sen Yan11
Estimated H-index: 11
(Jinan University),
Li Shihua76
Estimated H-index: 76
(Emory University),
Xiao-Jiang Li61
Estimated H-index: 61
(Emory University)
Abstract Animal models that can mimic human diseases are the important tools for investigating the pathogenesis of the diseases and finding a way for treatment. There is no doubt that small animal models have provided a wealth of information regarding disease pathogenesis and also offered widely used tools to develop therapeutic strategies. Rodent models have been very valuable for investigators to understand the mechanisms underlying misfolded protein-mediated neuronal dysfunction and behaviora...
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Published on Jan 7, 2019in The Neuroscientist 7.46
Shanshan Huang (Huazhong University of Science and Technology), Suiqiang Zhu (Huazhong University of Science and Technology)+ 1 AuthorsLi Shihua76
Estimated H-index: 76
(Emory University)
Polyglutamine (polyQ) diseases are a group of hereditary neurodegenerative disorders caused by expansion of unstable polyQ repeats in their associated disease proteins. To date, the pathogenesis of each disease remains poorly understood, and there are no effective treatments. Growing evidence has indicated that, in addition to neurodegeneration, polyQ-expanded proteins can cause a wide array of abnormalities in peripheral tissues. Indeed, polyQ-expanded proteins are ubiquitously expressed throug...
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Published on Dec 1, 2018in Cell Reports 8.03
Su Yang9
Estimated H-index: 9
(Emory University),
Li Shihua76
Estimated H-index: 76
(Emory University),
Xiao-Jiang Li61
Estimated H-index: 61
(Emory University)
Summary Virus-mediated expression of CRISPR/Cas9 is commonly used for genome editing in animal brains to model or treat neurological diseases, but the potential neurotoxicity of overexpressing bacterial Cas9 in the mammalian brain remains unknown. Through RNA sequencing (RNA-seq) analysis, we find that virus-mediated expression of Cas9 influences the expression of genes involved in neuronal functions. Reducing the half-life of Cas9 by tagging with geminin, whose expression is regulated by the ce...
2 Citations Source Cite
Published on Dec 1, 2018in Molecular Neurodegeneration 6.43
Jifeng Guo4
Estimated H-index: 4
(Central South University),
Yiting Cui3
Estimated H-index: 3
(Central South University)
+ 8 AuthorsSu Yang9
Estimated H-index: 9
(Emory University)
Background Spinocerebellar ataxia 17 (SCA17) belongs to the family of neurodegenerative diseases caused by polyglutamine (polyQ) expansion. In SCA17, polyQ expansion occurs in the TATA box binding protein (TBP) and leads to the misfolding of TBP and the preferential degeneration in the cerebellar Purkinje neurons. Currently there is no effective treatment for SCA17. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a recently identified neurotrophic factor, and increasing MANF expres...
5 Citations Source Cite
Published on Nov 29, 2018in Frontiers in Physiology 3.39
Su Yang9
Estimated H-index: 9
(Emory University),
Li Shihua76
Estimated H-index: 76
(Jinan University),
Xiao-Jiang Li61
Estimated H-index: 61
(Emory University)
All human behaviors, including the control of energy homeostasis, are ultimately mediated by neuronal activities in the brain. Neurotrophic factors represent a protein family that plays important roles in regulating neuronal development, function, and survival. It has been well established that canonical neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF), play important roles in the central regulation of energy homeostasis. Recently, a c...
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Published on May 1, 2018in Cell 31.40
Sen Yan11
Estimated H-index: 11
(Jinan University),
Zhuchi Tu7
Estimated H-index: 7
(Jinan University)
+ 18 AuthorsChengdan Lai4
Estimated H-index: 4
(Guangzhou Institutes of Biomedicine and Health)
Summary Huntington's disease (HD) is characterized by preferential loss of the medium spiny neurons in the striatum. Using CRISPR/Cas9 and somatic nuclear transfer technology, we established a knockin (KI) pig model of HD that endogenously expresses full-length mutant huntingtin (HTT). By breeding this HD pig model, we have successfully obtained F1 and F2 generation KI pigs. Characterization of founder and F1 KI pigs shows consistent movement, behavioral abnormalities, and early death, which are...
23 Citations Source Cite
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