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Weili Yang
Jinan University
13Publications
9H-index
298Citations
Publications 13
Newest
Published on Jun 1, 2019in Acta Neuropathologica18.17
Peng Yin1
Estimated H-index: 1
(JNU: Jinan University),
Xiangyu Guo9
Estimated H-index: 9
(JNU: Jinan University)
+ 7 AuthorsXiao-Jiang Li1
Estimated H-index: 1
(JNU: Jinan University)
The cytoplasmic accumulation of the nuclear TAR DNA-binding protein 43 (TDP-43) is a pathologic hallmark in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and other neurological disorders. However, most transgenic TDP-43 rodent models show predominant nuclear distribution of TDP-43 in the brain. By expressing mutant TDP-43 (M337V) in the brains of rhesus monkeys and mice, we verified that mutant TDP-43 is distributed in the cytoplasm of the monkey brain and that the majority o...
Published on Apr 1, 2019in Cell Research17.85
Weili Yang9
Estimated H-index: 9
(JNU: Jinan University),
Yunbo Liu1
Estimated H-index: 1
(Peking Union Medical College)
+ 12 AuthorsZhengyi Yang14
Estimated H-index: 14
(CAS: Chinese Academy of Sciences)
Published on May 1, 2018in Cell36.22
Sen Yan11
Estimated H-index: 11
(JNU: Jinan University),
Zhuchi Tu7
Estimated H-index: 7
(JNU: Jinan University)
+ 18 AuthorsChengdan Lai4
Estimated H-index: 4
(Guangzhou Institutes of Biomedicine and Health)
Summary Huntington's disease (HD) is characterized by preferential loss of the medium spiny neurons in the striatum. Using CRISPR/Cas9 and somatic nuclear transfer technology, we established a knockin (KI) pig model of HD that endogenously expresses full-length mutant huntingtin (HTT). By breeding this HD pig model, we have successfully obtained F1 and F2 generation KI pigs. Characterization of founder and F1 KI pigs shows consistent movement, behavioral abnormalities, and early death, which are...
Published on Dec 1, 2017in Nature Communications11.88
Su Yang9
Estimated H-index: 9
(Emory University),
Huiming Yang3
Estimated H-index: 3
(CSU: Central South University)
+ 7 AuthorsXiao-Jiang Li61
Estimated H-index: 61
(Emory University)
The hypothalamus has a vital role in controlling food intake and energy homeostasis; its activity is modulated by neuropeptides and endocrine factors. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a neurotrophic factor that is also localized in the endoplasmic reticulum (ER) in neurons. Here we show that MANF is highly enriched in distinct nuclei of the mouse hypothalamus, and that MANF expression in the hypothalamus is upregulated in response to fasting. Increasing or decreasing...
Published on Sep 1, 2017in Cell Stem Cell21.46
Xiao-Jiang Li61
Estimated H-index: 61
(Emory University),
Zhuchi Tu7
Estimated H-index: 7
(JNU: Jinan University)
+ 1 AuthorsLi Shihua76
Estimated H-index: 76
(Emory University)
Off-target effects and mosaicism are major concerns for applying CRISPR-Cas9 to correct genetic mutations. A recent article in Nature by Ma et al. (2017) uses an elegant CRISPR-Cas9 approach that repairs a genetic mutation in human embryos with negligible mosaicism and no off-target effects, bringing this editing tool closer to clinical application.
Published on Feb 1, 2017in Scientific Reports4.01
Zhuchi Tu7
Estimated H-index: 7
,
Weili Yang9
Estimated H-index: 9
+ 10 AuthorsSu Yang9
Estimated H-index: 9
Published on Apr 28, 2016in Frontiers in Molecular Neuroscience3.72
Weili Yang9
Estimated H-index: 9
(CAS: Chinese Academy of Sciences),
Zhuchi Tu7
Estimated H-index: 7
(CAS: Chinese Academy of Sciences)
+ 1 AuthorsXiao-Jiang Li61
Estimated H-index: 61
(CAS: Chinese Academy of Sciences)
CRISPR/Cas9 is now used widely to genetically modify the genomes of various species. The ability of CRISPR/Cas9 to delete DNA sequences and correct DNA mutations opens up a new avenue to treat genetic diseases that are caused by DNA mutations. In this review, we describe the advantages of using CRISPR/Cas9 to engineer genomic DNAs in animal embryos, as well as in specific regions or cell types in the brain. We also discuss how to apply CRISPR/Cas9 to establish animal models of neurodegenerative ...
Published on Dec 1, 2015in Molecular Neurodegeneration8.27
Zhuchi Tu7
Estimated H-index: 7
(CAS: Chinese Academy of Sciences),
Weili Yang9
Estimated H-index: 9
(CAS: Chinese Academy of Sciences)
+ 2 AuthorsXiao-Jiang Li61
Estimated H-index: 61
(CAS: Chinese Academy of Sciences)
Animal models are extremely valuable to help us understand the pathogenesis of neurodegenerative disorders and to find treatments for them. Since large animals are more like humans than rodents, they make good models to identify the important pathological events that may be seen in humans but not in small animals; large animals are also very important for validating effective treatments or confirming therapeutic targets. Due to the lack of embryonic stem cell lines from large animals, it has bee...
Published on Nov 1, 2015in Nature Communications11.88
FENGMang21
Estimated H-index: 21
(CAS: Chinese Academy of Sciences),
Y. P. Zhong1
Estimated H-index: 1
(ZJU: Zhejiang University)
+ 4 AuthorsHuaping Wang12
Estimated H-index: 12
(ZJU: Zhejiang University)
Quantum phase transitions play an important role in many-body systems and have been a research focus in conventional condensed-matter physics over the past few decades. Artificial atoms, such as superconducting qubits that can be individually manipulated, provide a new paradigm of realising and exploring quantum phase transitions by engineering an on-chip quantum simulator. Here we demonstrate experimentally the quantum critical behaviour in a highly controllable superconducting circuit, consist...
Published on Jul 1, 2015in Human Molecular Genetics4.54
Yongchang Chen11
Estimated H-index: 11
(Kunming University of Science and Technology),
Yinghui Zheng3
Estimated H-index: 3
(CAS: Chinese Academy of Sciences)
+ 12 AuthorsRuxiao Xing3
Estimated H-index: 3
(CAS: Chinese Academy of Sciences)
CRISPR/Cas9 has been used to genetically modify genomes in a variety of species, including non-human primates. Unfortunately, this new technology does cause mosaic mutations, and we do not yet know whether such mutations can functionally disrupt the targeted gene or cause the pathology seen in human disease. Addressing these issues is necessary if we are to generate large animal models of human diseases using CRISPR/Cas9. Here we used CRISPR/Cas9 to target the monkey dystrophin gene to create mu...
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