Coculture with noncardiac cells promoted maturation of human stem cell–derived cardiomyocyte microtissues

Cardiomyocytes derived from human pluripotent stem cells (hPSC‐CM) provided a promising cell source for cell therapy, drug screening, and disease modeling. However, hPSC‐CM are immature and phenotypically more similar to fetal rather than adult cardiomyocytes in vitro . We explored the impact of coculture of human embryonic stem cell–derived mesenchymal stem cells (hESC‐MSC) and endothelial cells (ECs) with human embryonic stem cells–derived...