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Journal of Cellular Biochemistry
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#1Safaa S. Hassan (Cairo University)H-Index: 4
#2Nashwa El-Khazragy (Ain Shams University)H-Index: 3
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Hepatitis C virus (HCV) infection is a major public health problem, having a high prevalence in Egypt. Leukemia and lymphoma have been associated with HCV infection. MicroRNA-155 (miR-155) has been reported to play a regulatory role in cancer, inflammation, and immune response to infection. The expression level of miR-155 in HCV viremic patients is controversial; although high miR-155 levels were demonstrated in HCV genotypes 1,2, and 3, low levels of miR-155 were detected in Egyptian patients w...
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#1Yanping Cheng (SEU: Southeast University)H-Index: 1
#2Sheng Yang (SEU: Southeast University)H-Index: 4
Last. Geyu Liang (SEU: Southeast University)H-Index: 14
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Lung cancer is one of the deadliest cancers worldwide. To increase the survival rate of lung cancer, it is necessary to explore specific prognosis markers. More and more evidence finds that noncoding RNA is closely associated with the survival of lung cancer, and cancer stem cells (CSCs) also play a significant role in the progress of lung cancer. The objective of this study is to find CSLCs genes that affect the prognosis of lung cancer. The differential expression of long noncoding RNAs (lncRN...
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Complement factor H-related 3 (CFHR3) is a protein-coding gene acting in various diseases. However, its prognostic values of CFHR3 in hepatocellular carcinoma (HCC) are not understandable. Therefore, we present a further study on CFHR3 in HCC. CFHR3 expression data were acquired from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC). We compared the differential expression of CFHR3 between the low-stage (stage I and II) and high-stage (stage III and IV) patient...
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#1Ana Maria Franchi (CONICET: National Scientific and Technical Research Council)H-Index: 24
#2A. Moreno‐Irusta (CONICET: National Scientific and Technical Research Council)
Last. Laura C. Giojalas (CONICET: National Scientific and Technical Research Council)H-Index: 18
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Cells can communicate with other neighboring or distant cells through the secretion of extracellular vesicles (EV), composed of a lipid bilayer and bearing surface molecules that allow them to recognize target cells. In this way, EV induce signaling via different mechanisms, modulating the physiological state of the recipient cell. EV have been identified in both male and female reproductive fluids, however, the possible role of EV isolated from female reproductive fluids has become an emerging ...
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#1Wen-Jing Liu (NPU: Northwestern Polytechnical University)H-Index: 1
#2Gang Zhao (JLU: Jilin University)
Last. Sheng-Xiang Lin (Laval University)H-Index: 24
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Breast cancer (BC) and prostate cancer (PC) are the second most common malignant tumors in women and men in western countries, respectively. The risks of death are 14% for BC and 9% for PC. Abnormal estrogen and androgen levels are related to carcinogenesis of the breast and prostate. Estradiol stimulates cancer development in BC. The effect of estrogen on PC is concentration-dependent, and estrogen can regulate androgen production, further affecting PC. Estrogen can also increase the risk of an...
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#1Abhijnya Vijayavittal Kanugovi (Stanford University)H-Index: 1
#2Chitra Joseph (Macquarie University)H-Index: 3
Last. Sreedhar Subbarao Amere (CCMB: Centre for Cellular and Molecular Biology)
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The Hsp90 chaperone has become the attractive pharmacological target to inhibit tumor cell proliferation. However, tumor cells can evolve with mechanisms to overcome Hsp90 inhibition. Using human neuroblastoma, we have investigated one such limitation. Here, we demonstrate that neuroblastoma cells overcome the interference of tumor suppressor p16(INK4a) in cell proliferation, which is due to its latent interaction with CDK4 and CDK6. Cells also displayed impedance to the pharmacological inhibiti...
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#1Rana Shafabakhsh (KAUMS: Kashan University of Medical Sciences)H-Index: 2
#2Hamed Mirzaei (KAUMS: Kashan University of Medical Sciences)H-Index: 34
Last. Zatollah Asemi (KAUMS: Kashan University of Medical Sciences)H-Index: 29
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Leukemia or cancer of blood is a well-known cancer, which affects a range of people from newborns to the very old. It is a public health problem throughout the world. By way of treatment, due to the lack of specific anticancer therapies, common treatments of leukemia lead to severe side effects. Nonspecific anticancer drugs result in inhibition of normal cell growth and thereby their necrosis. Moreover, drug resistance is an additional problem, which stands in the way of leukemia treatment. Thus...
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#1Meenakshi Vachher (DU: University of Delhi)H-Index: 1
#2Kriti Arora (DCE: Delhi Technological University)
Last. Bhupender Kumar (DU: University of Delhi)H-Index: 3
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Adipose tissue is an important source of adipokines involved in anti pro-inflammatory effects. Their involvement in certain cancers such as breast and colon cancer is known but in gliomas it remains unexplored till date. The aim of this study was to assess the status of adipokines as prognostic markers of gliomas (low grade gliomas [LGG] and glioblastoma mutiforme [GBM]). Expression status (messenger RNA [mRNA]), overall survival (OS) and disease-free survival (DFS) was identified using gene exp...
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#1Danelia Ramírez‐Ramírez (UAM: Universidad Autónoma Metropolitana)H-Index: 1
#2Monica L. Salgado-Lucio (IPN: Instituto Politécnico Nacional)
Last. Enrique O. Hernández-González (IPN: Instituto Politécnico Nacional)H-Index: 16
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Actin cytoskeleton remodeling is a critical process for the acquisition of fertilizing capacity by spermatozoa during capacitation. However, the molecular mechanism that regulates this process has not been fully elucidated. In somatic cells, Ras-related C3 botulinum toxin substrate 1 protein (Rac1) promotes the polymerization of actin by participating in the modeling of two structures: lamellipodia and adhesion complexes linked with the plasma membrane. Rac1 is expressed in mammalian spermatozoa...
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#1Dalong Sun (Fudan University)H-Index: 1
#2Tiancheng Luo (Fudan University)
Last. Si Zhang (Fudan University)H-Index: 10
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Tumor-associated macrophages (TAMs) have been considered as a major component of the tumor microenvironment. However, the crosstalk between M2-polarized tumor-associated macrophages (M2-TAMs) and intrahepatic cholangiocarcinoma (ICC) remains undetermined. In the present study, we aimed to clarify the role of M2-TAMs in ICC and the underlying mechanism. The in vitro assay demonstrated M2-TAMs promoted epithelial-mesenchymal transition (EMT) of ICC cells, resulting in enhanced cell invasion and me...
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