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Sara Pahlavan
Royan Institute
25Publications
6H-index
172Citations
Publications 27
Newest
#1Melika Parchehbaf-Kashani (Shahid Beheshti University)
#2Mohammadmajid Sepantafar (Royan Institute)H-Index: 5
Last.Sarah Rajabi (Royan Institute)H-Index: 4
view all 7 authors...
Abstract Cardiovascular diseases (CVD) are a major cause of mortality worldwide. Accessibility to heart tissue is limited due to sampling issues and lack of appropriate culture conditions. In addition, animal models are not an ideal choice for physiological, pharmacological, and fundamental evaluations in the cardiovascular field due to interspecies differences. Hence, there is an inevitable need for functional in vitro cardiac models. In this study, we have synthesized a novel electroconductive...
Source
#1Anna Meyfour (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 2
#2Sara Pahlavan (Royan Institute)H-Index: 6
Last.Ghasem Hosseini Salekdeh (Macquarie University)H-Index: 39
view all 5 authors...
Despite the small number of Y chromosome genes, their adequate expression is required for regulation of transcription, translation, and protein stability in males, not just for sex determination. In addition to the role in male fertility, the Y chromosome has a significant role in the development and sexual dimorphism of healthy and disease phenotypes. We observed that KDM5D along with its X-counterpart, KDM5C, are up-regulated during the cardiac mesoderm stage of development. Down-regulation of...
Source
#1Sadaf Vahdat (UT: University of Tehran)H-Index: 4
#2Sara Pahlavan (Royan Institute)H-Index: 6
Last.Hossein Baharvand (University of Science and Culture)H-Index: 44
view all 8 authors...
Cardiovascular progenitor cells (CPCs) derived from human pluripotent stem cells (hPSCs) are proposed to be invaluable cell sources for experimental and clinical studies. This wide range of applications necessitates large-scale production of CPCs in an in vitro culture system, which enables both expansion and maintenance of these cells. In this study, we aimed to develop a defined and efficient culture medium that uses signaling factors for large-scale expansion of early CPCs, called cardiogenic...
Source
#1Fatemeh Radmanesh (Shahid Beheshti University of Medical Sciences and Health Services)
#2Hamid Sadeghi Abandansari (Royan Institute)H-Index: 9
Last.Hossein Baharvand (University of Science and Culture)H-Index: 44
view all 8 authors...
Abstract Safe and efficient delivery of microRNA (miRNA) molecules is essential for their successful transition from research to the clinic setting. In the present study, we have used a bile acid, deoxycholic acid (DA), to modify 1.8 kDa branched polyethylenimine (bPEI1.8) and subsequently investigated gene delivery features of the resultant conjugates (PEI-DAn). We found significant differences between the PEI-DAn conjugates and conventional bPEIs with respect to miRNA condensation ability, buf...
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#1Fahimeh Varzideh (Royan Institute)H-Index: 3
#2Elena Mahmoudi (Royan Institute)H-Index: 2
Last.Sara Pahlavan (Royan Institute)H-Index: 6
view all 3 authors...
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#1Fahimeh Varzideh (Royan Institute)H-Index: 3
#2Sara Pahlavan (Royan Institute)H-Index: 6
Last.Hossein Baharvand (University of Science and Culture)H-Index: 44
view all 10 authors...
Abstract Human cardiomyocytes (CM) differentiated from pluripotent stem cells (PSCs) are relatively immature when generated in two-dimensional (2D) in vitro cultures, which limits their biomedical applications. Here, we devised a strategy to enhance maturation of human CM in vitro by assembly of three-dimensional (3D) cardiac organoids (CO) containing human embryonic stem cell-derived cardiac progenitor cells (hESC-CPCs), endothelial cells (ECs), and mesenchymal stem cells (MSCs). In contrast to...
5 CitationsSource
#1Zeinab Golgooni (Sharif University of Technology)
#2Sara Mirsadeghi (Royan Institute)H-Index: 1
Last.Hamid R. Rabiee (Sharif University of Technology)H-Index: 20
view all 7 authors...
An early characterization of drug-induced cardiotoxicity may be possible by combining comprehensive in vitro proarrhythmia assay and deep learning techniques. We aimed to develop a method to automatically detect irregular beating rhythm of field potentials recorded from human pluripotent stem cells (hPSC) derived cardiomyocytes (hPSC-CM) by multi-electrode array (MEA) system. We included field potentials from 380 experiments, which were labeled as normal or arrhythmic by electrophysiology expert...
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#1Sadaf VahdatH-Index: 4
#2Sara PahlavanH-Index: 6
Last.Hossein BaharvandH-Index: 44
view all 5 authors...
1 CitationsSource
#1Parisa Ghiasi (TMU: Tarbiat Modares University)H-Index: 3
#2Saman Hosseinkhani (TMU: Tarbiat Modares University)H-Index: 28
Last.Hossein Baharvand (University of Science and Culture)H-Index: 44
view all 7 authors...
2 CitationsSource
#1Anna Meyfour (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 2
#2Sara Pahlavan (Academic Center for Education, Culture and Research)H-Index: 6
Last.Ghasem Hosseini Salekdeh (Academic Center for Education, Culture and Research)H-Index: 39
view all 4 authors...
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