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Sara Pahlavan
Royan Institute
23Publications
6H-index
139Citations
Publications 23
Newest
Published on Jun 1, 2019in International Journal of Pharmaceutics4.21
Fatemeh Radmanesh1
Estimated H-index: 1
,
Hamid Sadeghi Abandansari9
Estimated H-index: 9
+ 5 AuthorsBahram Kazemi
Abstract Safe and efficient delivery of microRNA (miRNA) molecules is essential for their successful transition from research to the clinic setting. In the present study, we have used a bile acid, deoxycholic acid (DA), to modify 1.8 kDa branched polyethylenimine (bPEI 1.8 ) and subsequently investigated gene delivery features of the resultant conjugates (PEI-DA n ). We found significant differences between the PEI-DA n conjugates and conventional bPEIs with respect to miRNA condensation ability...
Published on Feb 1, 2019in Biomaterials10.27
Fahimeh Varzideh2
Estimated H-index: 2
(Royan Institute),
Sara Pahlavan6
Estimated H-index: 6
(Royan Institute)
+ 7 AuthorsHossein Baharvand42
Estimated H-index: 42
(University of Science and Culture)
Abstract Human cardiomyocytes (CM) differentiated from pluripotent stem cells (PSCs) are relatively immature when generated in two-dimensional (2D) in vitro cultures, which limits their biomedical applications. Here, we devised a strategy to enhance maturation of human CM in vitro by assembly of three-dimensional (3D) cardiac organoids (CO) containing human embryonic stem cell-derived cardiac progenitor cells (hESC-CPCs), endothelial cells (ECs), and mesenchymal stem cells (MSCs). In contrast to...
Zeinab Golgooni (Sharif University of Technology), Sara Mirsadeghi1
Estimated H-index: 1
(Royan Institute)
+ -3 AuthorsHamid R. Rabiee17
Estimated H-index: 17
(Sharif University of Technology)
An early characterization of drug-induced cardiotoxicity may be possible by combining comprehensive in vitro proarrhythmia assay and deep learning techniques. We aimed to develop a method to automatically detect irregular beating rhythm of field potentials recorded from human pluripotent stem cells (hPSC) derived cardiomyocytes (hPSC-CM) by multi-electrode array (MEA) system. We included field potentials from 380 experiments, which were labeled as normal or arrhythmic by electrophysiology expert...
Published on Jan 1, 2019in Journal of Cellular Physiology4.52
Parisa Ghiasi3
Estimated H-index: 3
(TMU: Tarbiat Modares University),
Saman Hosseinkhani26
Estimated H-index: 26
(TMU: Tarbiat Modares University)
+ 4 AuthorsHossein Baharvand42
Estimated H-index: 42
(University of Science and Culture)
Published on Apr 1, 2018in Proteomics3.11
Anna Meyfour2
Estimated H-index: 2
(Shahid Beheshti University of Medical Sciences and Health Services),
Sara Pahlavan6
Estimated H-index: 6
(Academic Center for Education, Culture and Research)
+ 1 AuthorsGhasem Hosseini Salekdeh36
Estimated H-index: 36
(Academic Center for Education, Culture and Research)
Published on Feb 1, 2018in Biomaterials10.27
Sarah Rajabi3
Estimated H-index: 3
(Royan Institute),
Sara Pahlavan6
Estimated H-index: 6
(Royan Institute)
+ 8 AuthorsBraunThomas61
Estimated H-index: 61
(MPG: Max Planck Society)
Abstract Bioengineering of whole hearts using human embryonic stem cells (hESCs)-derived cardiovascular progenitor cells (CPCs) and natural matrices is a promising approach to overcome organ donor shortage threatening millions of patients awaiting for heart transplantation. Here, we developed a novel strategy for generation of heart constructs by repopulating engineered decellularized rat hearts using hESCs-derived CPCs. Careful expansion of CPCs in a scalable stirred-suspension bioreactor combi...
Published on Dec 1, 2017in Journal of Proteome Research3.78
Anna Meyfour2
Estimated H-index: 2
,
Hassan Ansari4
Estimated H-index: 4
+ 5 AuthorsGhasem Hosseini Salekdeh36
Estimated H-index: 36
Despite evidence for sex-specific cardiovascular physiology and pathophysiology, the biological basis for this dimorphism remains to be explored. Apart from hormonal factors, gender-related characteristics may reside in the function of sex chromosomes during cardiac development. In this study, we investigated the differential expression of the male-specific region of the Y chromosome (MSY) genes and their X counterparts during cardiac differentiation of human embryonic stem cells (hESC). We obse...
Published on Dec 1, 2017in Journal of Proteome Research3.78
Anna Meyfour2
Estimated H-index: 2
,
Paria Pooyan2
Estimated H-index: 2
+ 4 AuthorsGhasem Hosseini Salekdeh36
Estimated H-index: 36
One of the main goals of Chromosome-Centric Human Proteome Project is to identify protein evidence for missing proteins (MPs). Here, we present a case study of the role of Y chromosome genes in organ development and how to overcome the challenges facing MPs identification by employing human pluripotent stem cell differentiation into cells of different organs yielding unprecedented biological insight into adult silenced proteins. Y chromosome is a male-specific sex chromosome which escapes meioti...
Published on Nov 13, 2017in The FASEB Journal5.39
Sara Pahlavan6
Estimated H-index: 6
(Academic Center for Education, Culture and Research),
Marziyeh Shalchi Tousi1
Estimated H-index: 1
(Academic Center for Education, Culture and Research)
+ 4 AuthorsHossein Baharvand42
Estimated H-index: 42
(University of Science and Culture)
Cardiac arrhythmias are major life-threatening conditions. The landmark discovery of induced pluripotent stem cells has provided a promising in vitro system for modeling hereditary cardiac arrhythmias as well as drug development and toxicity testing. Nowadays, nutraceuticals are frequently used as supplements for cardiovascular therapy. Here we studied the cardiac effects of hawthorn (Crataegus pentagyna) leaf extract using cardiomyocytes (CMs) differentiated from healthy human embryonic stem ce...
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