Fahimeh Varzideh
Royan Institute
Embryonic stem cellMolecular biologyMesenchymal stem cellProgenitor cellCell biology
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Publications 4
#1Fahimeh Varzideh (Royan Institute)H-Index: 3
#2Elena Mahmoudi (Royan Institute)H-Index: 2
Last. Sara Pahlavan (Royan Institute)H-Index: 6
view all 3 authors...
#1Fahimeh Varzideh (Royan Institute)H-Index: 3
#2Sara Pahlavan (Royan Institute)H-Index: 6
Last. Hossein Baharvand (University of Science and Culture)H-Index: 44
view all 10 authors...
Abstract Human cardiomyocytes (CM) differentiated from pluripotent stem cells (PSCs) are relatively immature when generated in two-dimensional (2D) in vitro cultures, which limits their biomedical applications. Here, we devised a strategy to enhance maturation of human CM in vitro by assembly of three-dimensional (3D) cardiac organoids (CO) containing human embryonic stem cell-derived cardiac progenitor cells (hESC-CPCs), endothelial cells (ECs), and mesenchymal stem cells (MSCs). In contrast to...
5 CitationsSource
#1Hamid Sadeghi Abandansari (Royan Institute)H-Index: 9
#2Mohammad Hossein Ghanian (Royan Institute)H-Index: 6
Last. Hossein Baharvand (University of Science and Culture)H-Index: 44
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Abstract Injectable hydrogels, which are used as scaffolds in cell therapy, provide a minimally invasive strategy to enhance cell retention and survival at injection site. However, till now, slow in situ gelation, undesired mechanical properties, and weak cell adhesion characteristics of reported hydrogels, have led to improper results. Here, we developed an injectable fully-interpenetrated polymer network (f-IPN) by integration of Diels-Alder (DA) crosslinked network and thermosensitive injecta...
6 CitationsSource
#1Sarah RajabiH-Index: 4
#2Sara PahlavanH-Index: 6
Last. Hossein BaharvandH-Index: 44
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Abstract Bioengineering of whole hearts using human embryonic stem cells (hESCs)-derived cardiovascular progenitor cells (CPCs) and natural matrices is a promising approach to overcome organ donor shortage threatening millions of patients awaiting for heart transplantation. Here, we developed a novel strategy for generation of heart constructs by repopulating engineered decellularized rat hearts using hESCs-derived CPCs. Careful expansion of CPCs in a scalable stirred-suspension bioreactor combi...
8 CitationsSource