S64. White Matter Abnormalities in the Anterior Section of the Left Cingulum Bundle Correlates With a Severe Course of Illness in Adults With Bipolar Disorder Who Have Been Prospectively Characterized Since Childhood for up to 18 Years of Illness

Different courses of Bipolar Disorder (BD) have important implications for psychosocial functioning and morbidity, yet neural correlates of these trajectories remain unclear. The Course and Outcome of Bipolar Youth (COBY) study has identified important demographic/clinical factors predicting different trajectories of BD...