The relationship between sleep duration, cognition and dementia: a Mendelian randomization study

Short and long sleep duration have been linked with poorer cognitive outcomes, but it remains unclear whether these associations are causal.We conducted the first Mendelian randomization (MR) study with 77 single-nucleotide polymorphisms (SNPs) for sleep duration using individual-participant data from the UK Biobank cohort (N = 395 803) and summary statistics from the International Genomics of Alzheimer's Project (N cases/controls = 17 008/37...