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Albert Henry
University College London
Genome-wide association studyOdds ratioGenetic associationHeart failureCoronary artery diseaseAtrial fibrillationDementiaMendelian randomizationConfidence intervalGeneticsCohortQuantitative trait locusBiologyGenetic architecture
4Publications
1H-index
8Citations
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Publications 4
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#1Sonia ShahH-Index: 36
#2Albert HenryH-Index: 1
Last. Mark ChaffinH-Index: 12
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#1Sonia Shah (UCL: University College London)H-Index: 36
#2Albert Henry (UCL: University College London)H-Index: 1
Last. R Thomas LumbersH-Index: 3
view all 146 authors...
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one o...
6 CitationsSource
#1Sonia Shah (UCL: University College London)H-Index: 36
#2Albert Henry (UCL: University College London)
Last. R Thomas Lumbers (UCL: University College London)H-Index: 3
view all 147 authors...
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report the largest GWAS meta-analysis of HF to-date, comprising 47,309 cases and 930,014 controls. We identify 12 independent associations with HF at 11 genomic loci, all of which demonstrate on...
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#1Albert Henry (UCL: University College London)
#2Michail Katsoulis (UCL: University College London)H-Index: 15
Last. Caroline Dale (UCL: University College London)H-Index: 19
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Background Short and long sleep duration have been linked with poorer cognitive outcomes, but it remains unclear whether these associations are causal. Methods We conducted the first Mendelian randomization (MR) study with 77 single-nucleotide polymorphisms (SNPs) for sleep duration using individual-participant data from the UK Biobank cohort (N = 395 803) and summary statistics from the International Genomics of Alzheimer’s Project (N cases/controls = 17 008/37 154) to investigate the potential...
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