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Metabolic analysis of adipose tissues in a rodent model of pre-pregnancy maternal obesity combined with offsprings on high-carbohydrate diet.

Published on Aug 1, 2019in Experimental Cell Research3.33
· DOI :10.1016/j.yexcr.2019.05.001
Andi Wang , Ting-Li Han9
Estimated H-index: 9
+ 5 AuthorsHua Zhang9
Estimated H-index: 9
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Abstract
Abstract Maternal obesity is associated with adverse effects on the health of offsprings. Consumption of a high-carbohydrate (HC) diet has been found to promote abnormal fatty acid metabolism in adipose tissue. Therefore, we hypothesised that maternal obesity combined with an offspring HC diet would alter the fatty acid metabolism of adipose tissue and subsequently contribute to offspring obesity. Lepr db/+ mice were used to model pre-pregnancy maternal obesity and the C57BL/6 wildtype were used as a control group. Offspring were fed either HC diet or a normal-carbohydrate (NC) diet after weaning. Brown adipose tissue (BAT) and white adipose tissue (WAT) were collected from offspring at 20 weeks of age and their fatty acid metabolome was characterized using gas chromatography-mass spectrometry. We found that HC diet increased the body weight of offspring (males increased by 14.70% and females increased by 1.05%) compared to control mothers. However, maternal obesity alone caused a 7.9% body weight increase in female offspring. Maternal obesity combined with an offspring HC diet resulted in dynamic alterations of the fatty acid profiles of adipose tissue in male offspring. Under the impact of a HC diet, the fatty acid metabolome was solely elevated in female WAT, whereas, the fatty acid metabolites in BAT showed a similar trend in the male and female offsprings. 6,9-octadecadienoic acid and 12,15-cis-octadecatrienoic acid were significantly affected in female WAT, in response to offspring consumption of a HC diet. Our study demonstrated that maternal obesity and offspring HC diet have different metabolic effects on adipose tissue in male and female offsprings.
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Published on Dec 1, 2018in Nutrition & Diabetes3.10
Jenifer Monks17
Estimated H-index: 17
(University of Colorado Denver),
David J. Orlicky32
Estimated H-index: 32
(University of Colorado Denver)
+ 10 AuthorsKayla Williamson1
Estimated H-index: 1
(Anschutz Medical Campus)
The current obesity epidemic has spurred exploration of the developmental origin of adult heath and disease. A mother’s dietary choices and health can affect both the early wellbeing and lifelong disease-risk of the offspring. To determine if changes in the mother’s diet and adiposity have long-term effects on the baby’s metabolism, independently from a prenatal insult, we utilized a mouse model of diet-induced-obesity and cross-fostering. All pups were born to lean dams fed a low fat diet but w...
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Lars Jacob Stovner57
Estimated H-index: 57
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Emma Nichols15
Estimated H-index: 15
+ 50 AuthorsLinh Phuong Doan1
Estimated H-index: 1
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Basma Damiri3
Estimated H-index: 3
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William S. Baldwin26
Estimated H-index: 26
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Wesley J. Tucker10
Estimated H-index: 10
(UTA: University of Texas at Arlington),
Brandon J. Sawyer10
Estimated H-index: 10
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Estimated H-index: 38
(ASU: Arizona State University)
Two similar high-intensity interval exercise (HIIE) protocols performed ∼18 h before ingestion of a high-energy fast food meal attenuated but did not entirely eliminate postprandial endothelial dysfunction in young men largely by improving fasting endothelial function. Both HIIE protocols produced essentially identical results, suggesting high reproducibility of HIIE effects.
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Mahshid Dehghan22
Estimated H-index: 22
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Andrew Mente30
Estimated H-index: 30
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+ 352 AuthorsAnders H. Rosengren84
Estimated H-index: 84
(University of Gothenburg)
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FrankM. Sacks3
Estimated H-index: 3
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Alice H. Lichtenstein79
Estimated H-index: 79
+ 9 AuthorsJennifer G. Robinson57
Estimated H-index: 57
Cardiovascular disease (CVD) is the leading global cause of death, accounting for 17.3 million deaths per year. Preventive treatment that reduces CVD by even a small percentage can substantially reduce, nationally and globally, the number of people who develop CVD and the costs of caring for them. This American Heart Association presidential advisory on dietary fats and CVD reviews and discusses the scientific evidence, including the most recent studies, on the effects of dietary saturated fat i...
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Maria Z. Alfaradhi6
Estimated H-index: 6
(Medical Research Council),
Laura C. Kusinski1
Estimated H-index: 1
(Medical Research Council)
+ 6 AuthorsSusan E. Ozanne64
Estimated H-index: 64
(Medical Research Council)
Obesity during pregnancy has a long-term effect on the health of the offspring including risk of developing the metabolic syndrome. Using a mouse model of maternal diet-induced obesity, we employed a genome-wide approach to investigate the microRNA (miRNA) and miRNA transcription profile in adipose tissue to understand mechanisms through which this occurs. Male offspring of diet-induced obese mothers, fed a control diet from weaning, showed no differences in body weight or adiposity at 8 weeks o...
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Katherine M. Flegal83
Estimated H-index: 83
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Deanna Kruszon-Moran33
Estimated H-index: 33
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Estimated H-index: 55
(CDC: Centers for Disease Control and Prevention)
Importance Between 1980 and 2000, the prevalence of obesity increased significantly among adult men and women in the United States; further significant increases were observed through 2003-2004 for men but not women. Subsequent comparisons of data from 2003-2004 with data through 2011-2012 showed no significant increases for men or women. Objective To examine obesity prevalence for 2013-2014 and trends over the decade from 2005 through 2014 adjusting for sex, age, race/Hispanic origin, smoking s...
Published on May 1, 2016in Lipids2.14
Shatha S. Hammad2
Estimated H-index: 2
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Shuaihua Pu8
Estimated H-index: 8
(UM: University of Manitoba),
Peter J. H. Jones64
Estimated H-index: 64
(UM: University of Manitoba)
Lack of consensus exists pertaining to the scientific evidence regarding effects of various dietary fatty acids on cardiovascular disease (CVD) risk. The objective of this article is to review current evidence concerning cardiovascular health effects of the main dietary fatty acid types; namely, trans (TFA), saturated (SFA), polyunsaturated (PUFA; n-3 PUFA and n-6 PUFA), and monounsaturated fatty acids (MUFA). Accumulating evidence shows negative health impacts of TFA and SFA; both may increase ...
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Artemis P. Simopoulos37
Estimated H-index: 37
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