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Hua Zhang
Chongqing Medical University
37Publications
9H-index
205Citations
Publications 37
Newest
Published on Jul 1, 2018in Experimental Cell Research 3.31
Chen Zhu (CQMU: Chongqing Medical University), Ting-Li Han9
Estimated H-index: 9
(CQMU: Chongqing Medical University)
+ 5 AuthorsHua Zhang9
Estimated H-index: 9
(CQMU: Chongqing Medical University)
Abstract Background Cognitive impairment is a brain dysfunction characterized by neuropsychological deficits in attention, working memory, and executive function. Maternal obesity and consumption of a high-fat diet (HFD) in the offspring has been suggested to have detrimental consequences for offspring cognitive function through its effect on the hippocampus and prefrontal cortex. Therefore, our study aimed to investigate the effects of maternal obesity and offspring HFD exposure on the brain me...
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Published on Jun 20, 2018in bioRxiv
Yong Yang , Jianxin Li1
Estimated H-index: 1
+ 5 AuthorsHua Zhang9
Estimated H-index: 9
Preeclampsia (PE) development is often associated with placental immune and inflammatory dysregulation, as well as endoplasmic reticulum (ER) stress. However, the mechanisms linking ER stress and inflammatory dysregulation to PE have not been clarified. It has been reported that thioredoxin-interacting protein (TXNIP), which can bind with and activate the NLR family pyrin domain containing 3 (NLRP3) inflammasome, plays a critical role in immune regulation. Recent experimental evidence suggests t...
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Published on May 1, 2018in Reproductive Sciences 2.55
Yu Yuan2
Estimated H-index: 2
(CQMU: Chongqing Medical University),
Nan Shan7
Estimated H-index: 7
(CQMU: Chongqing Medical University)
+ 10 AuthorsHua Zhang9
Estimated H-index: 9
(CQMU: Chongqing Medical University)
Preeclampsia (PE) is currently thought to be characterized by oxidative stress which may lead to endothelial dysfunction. The normal function of vascular endothelium is essential to vascular homeostasis. Previous studies have shown that steroid receptor coactivator 3 (SRC-3) interacts with estrogen receptors (ERs) which are involved in the vasoprotective effects of estrogen and is also associated with cell migration, invasion, and inflammation; however, its role in PE remains unclear. The main p...
3 Citations Source Cite
Published on Mar 1, 2018in Hypertension 6.82
Xuehai Chen1
Estimated H-index: 1
,
Chao Tong8
Estimated H-index: 8
+ 13 AuthorsYamin Liu1
Estimated H-index: 1
Normal placentation and a successful pregnancy depend on appropriate trophoblast cell migration and invasion. Inadequate trophoblast invasion and impaired spiral artery remodeling may lead to pregnancy-related disorders, such as preeclampsia. RPS4Y1 (ribosomal protein S4, Y-linked 1) is a member of the S4E family of ribosomal proteins. In this study, we found that RPS4Y1 levels were upregulated in placental samples collected from preeclamptic patients, when compared with the normotensive pregnan...
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Published on Jan 1, 2018in Frontiers in Microbiology 4.02
Ting-Li Han9
Estimated H-index: 9
(CQMU: Chongqing Medical University),
Richard D. Cannon36
Estimated H-index: 36
(University of Otago)
+ 5 AuthorsSilas G. Villas-Boas31
Estimated H-index: 31
(University of Auckland)
There are two glutamate dehydrogenases in the pathogenic fungus Candida albicans. One is a NAD+-dependent glutamate dehydrogenase (encoded by GDH2) responsible for the catabolism of glutamate into α-ketoglutarate and ammonium. The other is a NADPH-dependent glutamate dehydrogenase (encoded by GDH3) that catalyses the biosynthesis of glutamate from α-ketoglutarate. These two enzymes are part of the nitrogen and nicotinate/nicotinamide metabolic pathways, which have been identified in our previous...
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Published on Jan 29, 2018in Hypertension 6.82
Xuehai Chen1
Estimated H-index: 1
,
Chao Tong8
Estimated H-index: 8
+ 13 AuthorsYamin Liu1
Estimated H-index: 1
Normal placentation and a successful pregnancy depend on appropriate trophoblast cell migration and invasion. Inadequate trophoblast invasion and impaired spiral artery remodeling may lead to pregnancy-related disorders, such as preeclampsia. RPS4Y1 (ribosomal protein S4, Y-linked 1) is a member of the S4E family of ribosomal proteins. In this study, we found that RPS4Y1 levels were upregulated in placental samples collected from preeclamptic patients, when compared with the normotensive pregnan...
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Published on Jan 1, 2018in Mediators of Inflammation 3.55
Hong Chen2
Estimated H-index: 2
(CQMU: Chongqing Medical University),
Xiaobo Zhou2
Estimated H-index: 2
(CQMU: Chongqing Medical University)
+ 3 AuthorsHua Zhang9
Estimated H-index: 9
(CQMU: Chongqing Medical University)
Preeclampsia (PE) is a life-threatening pregnancy complication which is related to aggradation of risk regarding fetal and maternal morbidity and mortality. Dysregulation of systemic inflammatory response and dysfunction of trophoblast cells have been proposed to be involved in the development and progression of PE. Some studies have demonstrated that interleukin-33 (IL-33) is an immunomodulatory cytokine that is associated with the immune regulation of tumor cells. However, little is known whet...
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Published on Dec 1, 2017in BMJ Open 2.41
Jianlin Zhao1
Estimated H-index: 1
(CQMU: Chongqing Medical University),
Nan Shan7
Estimated H-index: 7
(CQMU: Chongqing Medical University)
+ 4 AuthorsHongbo Qi8
Estimated H-index: 8
(CQMU: Chongqing Medical University)
Objectives To assess the influence of second child intent on the delivery preferences and final delivery modes of nulliparous women, particularly caesarean delivery on maternal request (CDMR), after implementation of China’s two child policy. Design Cross sectional and prospective observational study. Setting A tertiary teaching hospital in Chongqing, China. Participants 1000 low risk nulliparous women were initially involved, and were divided into two groups based on their intent on having a se...
1 Citations Source Cite
Published on Oct 1, 2017in BMJ Open 2.41
Shuai Huang2
Estimated H-index: 2
(CQMU: Chongqing Medical University),
Ting-Ting Mo1
Estimated H-index: 1
(CQMU: Chongqing Medical University)
+ 8 AuthorsHongbo Qi8
Estimated H-index: 8
(CQMU: Chongqing Medical University)
Introduction Complex lipids are important constituents of the central nervous system. Studies have shown that supplementation with complex milk lipids (CML) in pregnancy may increase the level of fetal gangliosides (GA), with the potential to improve cognitive outcomes. Methods and analysis We aim to recruit approximately 1500 pregnant women in the first trimester (11–14 weeks) and randomise them into one of the three treatment groups: standard maternal milk formulation, CML-enhanced maternal mi...
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