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Hua Zhang
Chongqing Medical University
40Publications
11H-index
331Citations
Publications 40
Newest
#1Yang Yang (CQMU: Chongqing Medical University)H-Index: 1
Last.Ting-Li Han (CQMU: Chongqing Medical University)H-Index: 4
view all 9 authors...
The gut microbiome plays a fundamental role in host health and the fecal metabolome can be analysed to assess microbial activity and can be used as an intermediate phenotype monitoring the host-microbiome relationship. However, there is no established extraction protocol to study the fecal metabolome of giant pandas. The aim of this research is to optimize extraction of the fecal metabolome from adult and baby pandas for high throughput metabolomics analysis using gas chromatography-mass spectro...
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#1Andi Wang (CQMU: Chongqing Medical University)
#2Ting-Li Han (CQMU: Chongqing Medical University)H-Index: 9
Last.Hua Zhang (CQMU: Chongqing Medical University)H-Index: 11
view all 8 authors...
Abstract Maternal obesity is associated with adverse effects on the health of offsprings. Consumption of a high-carbohydrate (HC) diet has been found to promote abnormal fatty acid metabolism in adipose tissue. Therefore, we hypothesised that maternal obesity combined with an offspring HC diet would alter the fatty acid metabolism of adipose tissue and subsequently contribute to offspring obesity. Leprdb/+ mice were used to model pre-pregnancy maternal obesity and the C57BL/6 wildtype were used ...
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#1Thibaut Delplancke (CQMU: Chongqing Medical University)H-Index: 3
#2Jamie V. de Seymour (University of Auckland)H-Index: 6
Last.Philip N. Baker (CQMU: Chongqing Medical University)H-Index: 64
view all 8 authors...
The hair metabolome has been recognized as a valuable source of information in pregnancy research, as it provides stable metabolite information that could assist with studying biomarkers or metabolic mechanisms of pregnancy and its complications. We tested the hypothesis that hair segments could be used to reflect a metabolite profile containing information from both endogenous and exogenous compounds accumulated during the nine months of pregnancy. Segments of hair samples corresponding to the ...
10 CitationsSource
#1Xuyang Chen (CQMU: Chongqing Medical University)H-Index: 3
#2Jamie V. de Seymour (University of Auckland)H-Index: 6
Last.Philip N. Baker (CQMU: Chongqing Medical University)H-Index: 64
view all 8 authors...
Introduction Gestational diabetes mellitus (GDM) is impaired glucose tolerance first recognised during pregnancy; its development is associated with many adverse outcomes. Mechanisms of GDM development are not fully elucidated and few studies have used Chinese participants.
3 CitationsSource
#1Chen Zhu (CQMU: Chongqing Medical University)
#2Ting-Li Han (CQMU: Chongqing Medical University)H-Index: 9
Last.Hua Zhang (CQMU: Chongqing Medical University)H-Index: 11
view all 8 authors...
Abstract Background Cognitive impairment is a brain dysfunction characterized by neuropsychological deficits in attention, working memory, and executive function. Maternal obesity and consumption of a high-fat diet (HFD) in the offspring has been suggested to have detrimental consequences for offspring cognitive function through its effect on the hippocampus and prefrontal cortex. Therefore, our study aimed to investigate the effects of maternal obesity and offspring HFD exposure on the brain me...
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#2Jianxin LiH-Index: 1
Last.Hua ZhangH-Index: 11
view all 8 authors...
Preeclampsia (PE) development is often associated with placental immune and inflammatory dysregulation, as well as endoplasmic reticulum (ER) stress. However, the mechanisms linking ER stress and inflammatory dysregulation to PE have not been clarified. It has been reported that thioredoxin-interacting protein (TXNIP), which can bind with and activate the NLR family pyrin domain containing 3 (NLRP3) inflammasome, plays a critical role in immune regulation. Recent experimental evidence suggests t...
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#1Jamie V. de Seymour (University of Auckland)H-Index: 6
#2Stephanie Tu (Linköping University)H-Index: 1
Last.Karolina Sulek (UCPH: University of Copenhagen)H-Index: 10
view all 7 authors...
Introduction Intrahepatic cholestasis of pregnancy (ICP) is a common maternal liver disease; development can result in devastating consequences, including sudden fetal death and stillbirth. Currently, recognition of ICP only occurs following onset of clinical symptoms.
1 CitationsSource
#1Yu Yuan (CQMU: Chongqing Medical University)H-Index: 2
#2Nan Shan (CQMU: Chongqing Medical University)H-Index: 8
Last.Hongbo Qi (CQMU: Chongqing Medical University)H-Index: 12
view all 13 authors...
Preeclampsia (PE) is currently thought to be characterized by oxidative stress which may lead to endothelial dysfunction. The normal function of vascular endothelium is essential to vascular homeostasis. Previous studies have shown that steroid receptor coactivator 3 (SRC-3) interacts with estrogen receptors (ERs) which are involved in the vasoprotective effects of estrogen and is also associated with cell migration, invasion, and inflammation; however, its role in PE remains unclear. The main p...
6 CitationsSource
#1Xuehai ChenH-Index: 2
#2Chao TongH-Index: 9
Last.Hongbo QiH-Index: 12
view all 16 authors...
Normal placentation and a successful pregnancy depend on appropriate trophoblast cell migration and invasion. Inadequate trophoblast invasion and impaired spiral artery remodeling may lead to pregnancy-related disorders, such as preeclampsia. RPS4Y1 (ribosomal protein S4, Y-linked 1) is a member of the S4E family of ribosomal proteins. In this study, we found that RPS4Y1 levels were upregulated in placental samples collected from preeclamptic patients, when compared with the normotensive pregnan...
2 CitationsSource
#1Ting-Li Han (CQMU: Chongqing Medical University)H-Index: 9
#2Richard D. Cannon (University of Otago)H-Index: 37
Last.Silas G. Villas-Boas (University of Auckland)H-Index: 34
view all 8 authors...
There are two glutamate dehydrogenases in the pathogenic fungus Candida albicans. One is a NAD+-dependent glutamate dehydrogenase (encoded by GDH2) responsible for the catabolism of glutamate into α-ketoglutarate and ammonium. The other is a NADPH-dependent glutamate dehydrogenase (encoded by GDH3) that catalyses the biosynthesis of glutamate from α-ketoglutarate. These two enzymes are part of the nitrogen and nicotinate/nicotinamide metabolic pathways, which have been identified in our previous...
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