Experimental Cell Research
Papers 23856
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#1Ying Feng (SCUT: South China University of Technology)
#2Cunjing Zheng (SYSU: Sun Yat-sen University)
Last.Zhongdao Wu (SYSU: Sun Yat-sen University)H-Index: 22
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Abstract Background Angiostrongylus cantonensis (A. cantonensis) is a foodborne parasite that can invade the central nervous system (CNS), resulting in eosinophilic meningitis (EM). However, the mechanism by which A. cantonensis causes eosinophilic infiltration into CNS is not well understood. Methods In this study eosinophilic infiltration into the CNS caused by A. cantonensis was assessed based on eosinophil counts and evaluation of interleukin (IL)-5 and −13 levels by real-time PCR in brain o...
#1Wei-long Zhang (Sichuan University)
#2Sha-sha Wang (Sichuan University)H-Index: 6
Last.Xinhua Liang (Sichuan University)H-Index: 19
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Abstract Great attention has been attached to explore the association between oral bacteria and oral cancer. Recently, four common inhabitants of oral cavity, Porphyromonas gingivalis, Fusobacterium nucleatum, Treponema denticola and Streptococcus anginosus, have been identified as potential etiologic bacterial agents for oral carcinogenesis. They might promote the oncogenesis and progression of oral cancer by induction of chronic inflammation, enhancement of migration and invasiveness, inhibiti...
#1Wei Li (SEU: Southeast University)H-Index: 2
#2Yunting Zhou (SEU: Southeast University)H-Index: 1
Last.Zilin Sun (SEU: Southeast University)H-Index: 13
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Abstract Background Islet stellate cells (ISCs) play a critical role in islet fibrosis, contributing to the progression of pancreatic diseases. Previous studies have focused on fibrosis-associated activated ISCs obtained by standard islet explant techniques. However, in vitro models of quiescent ISCs (qISCs) are lacking. This study aims to develop a method to isolate qISCs and analyze their phenotype during activation. Methods Immunofluorescence staining was applied to localize ISCs in normal hu...
#1Nicola Jeffery (University of Exeter)H-Index: 2
#2Lorna W. Harries (University of Exeter)H-Index: 37
Abstract Altered expression of miRNAs is evident in the islets of diabetic human donors, but the effects of specific aspects of the diabetic microenvironment and identity of gene ontology pathways demonstrating target gene enrichment in response to each is understudied. We assessed changes in the miRNA milieu in response to high/low glucose, hypoxia, dyslipidaemia and inflammatory factors in a humanised EndoC-βH1 beta cell culture system and performed miRPath analysis for each treatment individu...
#1Sarah R. Barger (State University of New York Upstate Medical University)H-Index: 1
#2Michael L. James (State University of New York Upstate Medical University)H-Index: 4
Last.Vladimir Sirotkin (State University of New York Upstate Medical University)H-Index: 11
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Abstract In both unicellular and multicellular organisms, long-tailed class I myosins function in clathrin-mediated endocytosis. Myosin 1e (Myo1e) in vertebrates and Myo1 in fission yeast have similar domain organization, yet whether these proteins or their individual protein domains are functionally interchangeable remains unknown. In an effort to assess functional conservation of class I myosins, we tested whether human Myo1e could replace Myo1 in fission yeast Schizosaccharomyces pombe and fo...
#1Shuai Liu (SDU: Shandong University)H-Index: 6
#2Xiaoli Liu (SDU: Shandong University)
Last.Zuohui Zhao (SDU: Shandong University)H-Index: 5
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Abstract Hydroxyacyl-CoA dehydrogenase alpha subunit (HADHA) is a key lipid metabolic enzyme with a novel role in carcinogenesis. We previously reported that HADHA, a prognostic marker, was downregulated in clear cell renal cell carcinoma (ccRCC). Herein, the tumor inhibitory role of HADHA overexpression in ccRCC was investigated further. The quantitative proteomic analysis displayed that a total of 1293 and 1293 proteins were identified in HADHA overexpressed 786-O-hadha and vector-transfected ...
#1Miao Chen (SDNU: Shandong Normal University)H-Index: 3
#2Yu Cao (SDNU: Shandong Normal University)
Last.Min Liu (SDNU: Shandong Normal University)H-Index: 6
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Abstract End binding protein 1 (EB1) is a key regulator of microtubule dynamics that orchestrates hierarchical interaction networks at microtubule plus ends to control proper cell division. EB1 activity is known to be regulated by serine/threonine phosphorylation; however, how tyrosine phosphorylation affects EB1 activity remains poorly understood. In this study, we mapped the tyrosine phosphorylation pattern of EB1 in synchronized cells and identified two tyrosine phosphorylation sites (Y217 an...
#1Qingguo Gu ('SMMU': Second Military Medical University)H-Index: 2
#2Yibin Luo ('SMMU': Second Military Medical University)
Last.Xinwei Wang ('SMMU': Second Military Medical University)H-Index: 16
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Abstract Osteosarcoma is the most common malignancy of bone that occurs in young adults and children, with a five-year survival rate of 60–70%. Metastasis of osteosarcoma maintains an even poorer prognosis. GREM1 plays an important role in regulating organogenesis, body patterning, and tissue differentiation. However, there are limited studies on GREM1 in osteosarcomas. This study was carried out to characterize the expression and function of GREM1 in osteosarcoma cells, thus extending our under...
#1Chong Zhang (Xinxiang Medical University)
#2Yan Qu (Xinxiang Medical University)
Last.Juntian Liu (Xi'an Jiaotong University)
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Abstract LncRNA plays a vital role in many diseases, and abnormal expression of LncRNA has been reported in many types of tumors. In this study, we analyzed the available public TCGA and GEO databases, and found that the expression of SNHG3 was increased in clear cell renal cell carcinoma (ccRCC), which was positively correlated with many clinicopathological parameters, and the higher expression of SNHG3 predicted worse clinical prognosis. Functional experiments indicated that knockdown of SNHG3...
#1Kazuya Hiroshima (Chiba University)H-Index: 1
#2Masashi Shiiba (Chiba University)H-Index: 28
Last.Katsuhiro Uzawa (Chiba University)H-Index: 30
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Abstract Tetraspanin 15 (Tspan15) is a member of the tetraspanin family, which is associated with various biological events and several diseases, however, its role in human oral squamous cell carcinoma (OSCC) remains unknown. The current study aimed to clarify the role of Tspan15 in OSCC. The mRNA and protein expression levels of Tspan15 were up-regulated in OSCC cases and OSCC-derived cell lines. Significant up-regulated Tspan15 expression was found in the advanced OSCC cases; primary tumoral s...
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Molecular biology
Cell biology