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Experimental Cell Research
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#1Sung-Ho KimH-Index: 3
#2Qing-Mei PeiH-Index: 2
Last. Jiang-Bo LiuH-Index: 2
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Abstract Mucins are major macromolecular components of lung mucus that are mainly responsible for the viscoelastic property of mucus. MUC5AC is a major mucin glycoprotein that is hypersecreted in asthmatic individuals. Vascular endothelial growth factor (VEGF) has been implicated in inflammatory and airway blood vessel remodeling in asthmatics. Our previous studies indicate that VEGF upregulates MUC5AC expression by interacting with VEGF receptor 2 (VEGFR2). It has been shown that dexamethasone ...
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#1Naomi Matsumoto (Iwate Medical University)H-Index: 3
#2Reina Matsukawa (Iwate Medical University)
Last. Mayumi Nakanishi-Matsui (Iwate Medical University)H-Index: 13
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Abstract The a3 isoform of vacuolar-type proton-pumping ATPase (V-ATPase) is essential for bone resorption by osteoclasts. Although more than 90 mutations of the human a3 gene have been identified in patients with infantile malignant osteopetrosis, it is unclear whether they lead to osteoclast dysfunction. We have established an in vitro assay to induce osteoclasts from spleen macrophages derived from a3-knockout mice. Here, we examined the effects of these mutations in a3-knockout osteoclasts. ...
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#1Marielle Afanassieff (Lyon College)H-Index: 2
#2Florence Perold (Lyon College)
Last. Nathalie Beaujean (Lyon College)H-Index: 1
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Abstract Both embryo-derived (ESC) and induced pluripotent stem cell (iPSC) lines have been established in rabbit. They exhibit the essential characteristics of primed pluripotency. In this review, we described their characteristic features at both molecular and functional levels. We also described the attempts to reprogram rabbit pluripotent stem cells (rbPSCs) toward the naive state of pluripotency using methods established previously to capture this state in rodents and primates. In the last ...
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#1Yongming Xi (Qingdao University)H-Index: 1
#2Hui Huang (Qingdao University)
Last. Yan Chen (UHN: University Health Network)H-Index: 1
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Abstract Tissue inhibitor of metalloproteinase 1 (TIMP1) has various biological activities including the regulation of cell growth and differentiation. However, its role in bone homeostasis and remodeling remains poorly understood. In this study, we investigate the effects of TIMP1 on osteoblast and osteoclast activity at both cellular and molecular level using siRNA-mediated knockdown technique. Our results show that knockdown of TIMP1 stimulates proliferation and survival, but decreases apopto...
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#1Adeleh Taei (University of Science and Culture)H-Index: 13
#2Paniz Rasooli (Royan Institute)
Last. Hossein Baharvand (University of Science and Culture)H-Index: 44
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Abstract Pluripotent cells transiently develop during peri-implantation embryogenesis and have the capacity to convert into three embryonic lineages. Two typical states of pluripotency, naive and primed, can be experimentally induced in vitro. The in vitro naive state can be stabilized in response to environmental inductive cues via a unique transcriptional regulatory program. However, interference with various signaling pathways creates a spectrum of alternative pluripotent cells that display d...
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#1D.D. Ehnes (UW: University of Washington)
#2Assis M. Hussein (UW: University of Washington)H-Index: 1
Last. Hannele Ruohola-Baker (UW: University of Washington)H-Index: 39
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Abstract Since epigenetic modifications are a key driver for cellular differentiation, the regulation of these modifications is tightly controlled. Interestingly, recent studies have revealed metabolic regulation for epigenetic modifications in pluripotent cells. As metabolic differences are prominent between naive (pre-implantation) and primed (post-implantation) pluripotent cells, the epigenetic changes regulated by metabolites has become an interesting topic of analysis. In this review we dis...
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#1Xiongwen Cao (Yale University)
#2Sarah A. Slavoff (Yale University)H-Index: 11
Abstract Recent ribosome profiling and proteomic studies have revealed the presence of thousands of novel coding sequences, referred to as small open reading frames (sORFs), in prokaryotic and eukaryotic genomes. These genes have defied discovery via traditional genomic tools not only because they tend to be shorter than standard gene annotation length cutoffs, but also because they are, as a class, enriched in sequence properties previously assumed to be unusual, including non-AUG start codons....
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#1R.A. Flickinger (SUNY: State University of New York System)H-Index: 7
Abstract The degree of polymorphism, i.e., DNA sequence divergence, of short AT-rich tandemly arranged simple sequence repeats at or near promoters and 5′- untranslated regions of mRNA may quantitatively regulate transcription of tissue-specific genes. Less polymorphic repeats allow greater gene expression. Preferential binding of hypophosphorylated H1 histone to these repeats may diminish binding of transcription factors. Preferential binding of hypophosphorylated high mobility group chromatin ...
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